Hormone replacement: Therapeutic strategies in the treatment of Alzheimer's disease and ageing-related cognitive disorders
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abstract
While the incidence of cognitive disorders such as Alzheimer's disease (AD) is increasing among the ageing populations of Europe and North America, few therapeutic agents have been identified for effective disease management. Substantial recent evidence suggests that the neurological circuits targeted by AD are also sensitive to gonadal hormones such as oestrogen. This review examines the evidence for hormone replacement therapy as a possible strategy for the management of ageing-related cognitive disorders, emphasising possible cellular/molecular actions of oestrogen. We examine the recent patent literature for promising trends in hormone-related therapeutics, especially advances related to the development of tissue-selective oestrogenic compounds. We also review the strategy of combining oestrogen with other compounds to increase their therapeutic efficacy.
