Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat Academic Article uri icon

abstract

  • The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.

author list (cited authors)

  • Guo-Ross, S. X., Jones, K. H., Shetty, A. K., Wilson, W. A., & Swartzwelder, H. S.

citation count

  • 25

publication date

  • May 2003