Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat. Academic Article

abstract

• The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.

authors

• Shetty, Ashok

published proceedings

• Neurosci Lett

author list (cited authors)

• Guo-Ross, S. X., Jones, K. H., Shetty, A. K., Wilson, W. A., & Swartzwelder, H. S.

citation count

• 25

complete list of authors

• Guo-Ross, Shirley X||Jones, Katherine H||Shetty, Ashok K||Wilson, Wilkie A||Swartzwelder, H Scott

publication date

• January 2003

publisher

• Elsevier  Publisher

published in

• NEUROSCIENCE LETTERS  Journal

keywords

• Animals
• Animals, Newborn
• Cerebral Cortex
• Choline
• Choline Deficiency
• Diet
• Dizocilpine Maleate
• Excitatory Amino Acid Antagonists
• Female
• Gyrus Cinguli
• Neurons
• Nootropic Agents
• Pregnancy
• Prenatal Exposure Delayed Effects
• Rats
• Rats, Sprague-Dawley

Digital Object Identifier (DOI)

• 10.1016/s0304-3940(03)00119-8

start page

• 161

end page

• 163

volume

• 341

issue

• 2

URL

• http://dx.doi.org/10.1016/s0304-3940(03)00119-8