Experimental and Computational Studies on Cobalt(I)Catalyzed Regioselective Allylic Alkylation Reactions Academic Article uri icon

abstract

  • AbstractHere, we report the development of cobalt(I)catalyzed regioselective allylic alkylation reactions of tertiary allyl carbonates with 1,3dicarbonyl compounds. A family of welldefined tetrahedral cobalt(I) complexes bearing commercially available bidentate bis(phosphine) ligands [(P,P)Co(PPh3)Cl] are synthesized and explored as catalysts in allylic alkylation reactions. The catalyst [(dppp)Co(PPh3)Cl] (dppp=1,3Bis(diphenylphosphino)propane) enables the alkylation of a large variety of tertiary allyl carbonates with high yields and excellent regioselectivity for the branched product. Remarkably, this methodology is selective for the activation of tertiary allyl carbonates even in the presence of secondary allyl carbonates. This contrasts with the selectivity observed in cobaltcatalyzed allylic alkylations enabled by visible light photocatalysis. Mechanistic insights by means of experimental and computational investigations support a Co(I)/Co(III) catalytic cycle.

published proceedings

  • Angewandte Chemie

author list (cited authors)

  • Andreetta, P., Martin, R. T., Souilah, C., RenteraGmez, . ., Song, Z., Bayat, Y. K., ... Casitas, A.

citation count

  • 0

complete list of authors

  • Andreetta, Philip||Martin, Robert T||Souilah, Charafa||Rentería‐Gómez, Ángel||Song, Zhihui||Bayat, Yas Khorramshahi||Ivlev, Sergei||Gutierrez, Osvaldo||Casitas, Alicia

publisher