Relationship of uric acid to body composition, heart disease risk factors and energy expenditure
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abstract
848 sedentary, obese women (4711 yrs, 9218 kg, 1637 cm, 454% body fat) were medically screened prior to participation in an exercise and weight loss program. Medical data and fasting blood samples were collected and a correlation analysis was used to examine relationships between baseline uric acid, body composition and associated risk factors for heart disease. Baseline uric acid levels were significantly correlated to several measures of body composition: body mass (r=0.154), waist circumference (r=0.142), hip circumference (r=0.145), DEXA fat mass (r=0.155), DEXA fatfree mass (r=0.122) and DEXA % body fat (r=0.106). Higher uric acid levels were also positively correlated with higher triglyceride levels (r=0.091), total cholesterol: HDL ratio (r=0.097) and lower HDL cholesterol (r= 0.097). Uric acid levels were positively correlated with baseline measures of resting energy expenditure (r=0.130). Uric acid levels were not significantly correlated with age (r= 0.012), resting heart rate (r= 0.021), systolic blood pressure (r=0.032), diastolic blood pressure (r=0.055), total cholesterol (r=0.023), LDL cholesterol (r=0.054) and blood glucose levels (r= 0.041). Although correlations are modest, data from this sample (n=848) suggest that maintenance of uric acid may be an important consideration in managing obesity and metabolic syndrome.
