Serum pepsinogen-A, canine pancreatic lipase immunoreactivity, and C-reactive protein as prognostic markers in dogs with gastric dilatation-volvulus. Academic Article uri icon


  • BACKGROUND: Pepsinogens are proenzymes secreted by gastric chief cells. In humans, their serum concentrations reflect gastric mucosal morphological and functional status. OBJECTIVES: To evaluate serum canine pepsinogen-A (cPG-A), C-reactive protein (CRP), and canine pancreatic lipase immunoreactivity (cPLI) concentrations in dogs with gastric dilatation-volvulus (GDV). ANIMALS: Sixty-six dogs presented with GDV and 79 healthy controls. METHODS: Blood was collected prospectively, and records retrospectively reviewed. RESULTS: Median cPG-A concentration was higher in GDV dogs (median, 397 g/L; range, 37-5,410) compared to controls (median, cPG-A 304 g/L; range, 18-848; P = .07). Mortality rate in GDV dogs was 22.7%. In nonsurvivors of GDV, median cPG-A was higher compared to survivors (median, 746 g/L; range, 128-5,409 versus median, 346; range, 36-1,575, respectively; P = .003). The proportion of dogs with increased cPG-A increased with gastric wall damage score (P = .007). An ROC analysis of cPG-A as a predictor of death showed an area under the curve (AUC) of 0.75, higher than lactate (AUC 0.66), and corresponded to a sensitivity and specificity of 53% and 88%, respectively. CRP was increased in 48 dogs (75%), cPLI was >200 g/L in 26 dogs (39.4%) and >400 g/L in 12 dogs (18.2%) but both analytes had no association with outcome. CONCLUSIONS: Presurgical cPG-A concentration was positively and significantly associated with gastric wall lesion severity, but, based on ROC analysis, it was only a moderate outcome predictor. CRP and cPLI were commonly increased in dogs with GDV.

published proceedings

  • J Vet Intern Med

author list (cited authors)

  • Israeli, I., Steiner, J., Segev, G., Kass, P. H., Suchodolski, J. S., Sattasathuchana, P., ... Aroch, I.

citation count

  • 24

complete list of authors

  • Israeli, I||Steiner, J||Segev, G||Kass, PH||Suchodolski, JS||Sattasathuchana, P||Bruchim, Y||Yudelevitch, S||Aroch, I

publication date

  • July 2012