Serum calprotectin concentrations in dogs with idiopathic inflammatory bowel disease. Academic Article uri icon

abstract

  • OBJECTIVE: To measure serum calprotectin concentration in dogs with inflammatory bowel disease (IBD) before and after initiation of treatment and evaluate its correlation with a clinical scoring system (canine IBD activity index), serum canine C-reactive protein concentration, and severity of histopathologic changes. ANIMALS: 34 dogs with idiopathic IBD and 139 healthy control dogs. PROCEDURES: From dogs with IBD, blood samples were collected immediately before (baseline) and 3 weeks after initiation of 1 of 2 treatments: prednisone (1 mg/kg, PO, q 12 h; n = 21) or a combination of prednisone and metronidazole (10 mg/kg, PO, q 12 h; 13). Blood samples were collected once from each of the control dogs. For all samples, serum calprotectin concentration was determined via radioimmunoassay. RESULTS: Mean serum calprotectin concentrations for dogs with IBD at baseline (431.1 μg/L) and 3 weeks after initiation of treatment (676.9 μg/L) were significantly higher, compared with that (219.4 μg/L) for control dogs, and were not significantly correlated with the canine IBD activity index, serum C-reactive protein concentration, or severity of histopathologic changes. The use of a serum calprotectin concentration of ≥ 296.0 μg/L as a cutoff had a sensitivity of 82.4% (95% confidence interval, 65.5% to 93.2%) and specificity of 68.4% (95% confidence interval, 59.9% to 76.0%) for distinguishing dogs with idiopathic IBD from healthy dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Serum calprotectin concentration may be a useful biomarker for the detection of inflammation in dogs, but the use of certain drugs (eg, glucocorticoids) appears to limit its clinical usefulness.

published proceedings

  • Am J Vet Res

altmetric score

  • 0.25

author list (cited authors)

  • Heilmann, R. M., Jergens, A. E., Ackermann, M. R., Barr, J. W., Suchodolski, J. S., & Steiner, J. M.

citation count

  • 33

complete list of authors

  • Heilmann, Romy M||Jergens, Albert E||Ackermann, Mark R||Barr, James W||Suchodolski, Jan S||Steiner, Jörg M

publication date

  • December 2012