Serum cobalamin and methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or other acute enteropathies.
Academic Article
Overview
Research
Identity
Other
View All
Overview
abstract
BACKGROUND: Low serum cobalamin concentrations have been associated with ileal malabsorption in dogs with chronic enteropathy. Increased serum methylmalonic acid (MMA) concentrations indicate cobalamin deficiency on a cellular level. Few studies have evaluated serum cobalamin concentrations or methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or nonparvoviral acute enteropathies. OBJECTIVES: Evaluate serum cobalamin and methylmalonic acid concentrations in juvenile dogs (6weeks to 10months old) with parvoviral enteritis or nonparvoviral acute enteropathy. ANIMALS: Thirty-one juvenile dogs with parvoviral enteritis, 29 dogs with nonparvoviral acute diarrhea (NPVAD), and 40 healthy juvenile control dogs. METHODS: Single-center, prospective, observational, cross-sectional study. Serum cobalamin and, when sufficient serum was available, MMA concentrations were measured. RESULTS: Most serum cobalamin concentrations were within the adult reference interval. Serum cobalamin concentrations in healthy dogs (median, 848ng/L; range, 293-1912ng/L) were significantly higher than in dogs with parvoviral enteritis (P=.0002; median, 463ng/L; range, <150-10000ng/L) or dogs with NPVAD (P=.02; median, 528ng/L; range, 160-8998ng/L). Serum MMA concentrations were not significantly different between groups (healthy dogs: median, 796nmol/L; range, 427-1933nmol/L; parvoviral enteritis: median, 858nmol/L; range, 554-3424nmol/L; NPVAD: median, 764nmol/L; range, 392-1222nmol/L; P=.1). CONCLUSIONS AND CLINICAL IMPORTANCE: Juvenile dogs with parvoviral enteritis or NPVAD had lower serum cobalamin concentrations than healthy juvenile dogs. However, based on serum MMA concentrations cellular cobalamin deficiency was not apparent.
