Campylobacter pylori detected noninvasively by the 13C-urea breath test. Academic Article

abstract

• The high endogenous urease activity of Campylobacter pylori was exploited in a non-invasive test for the presence of this organism in the stomach. When 13C-urea was administered orally after a test meal, urea-derived 13CO2 appeared in the respiratory CO2 of infected individuals at a constant rate for greater than 100 min. The test was validated in 26 individuals who underwent both the 13C-urea breath test and endoscopic biopsy of the antral mucosa for culture and histological examination. Each positive breath test proved to be correlated with a positive culture or Warthin-Starry silver stain of a mucosal biopsy specimen, or both.

authors

• Boutton, Thomas

published proceedings

• Lancet

altmetric score

• 6

author list (cited authors)

• Graham, D. Y., Klein, P. D., Evans, D. J., Evans, D. G., Alpert, L. C., Opekun, A. R., & Boutton, T. W.

citation count

• 620

complete list of authors

• Graham, DY||Klein, PD||Evans, DJ||Evans, DG||Alpert, LC||Opekun, AR||Boutton, TW

publication date

• May 1987

publisher

• Elsevier  Publisher

published in

• The Lancet  Journal

keywords

• Adult
• Breath Tests
• Campylobacter
• Campylobacter Infections
• Carbon Dioxide
• Carbon Isotopes
• Evaluation Studies As Topic
• Female
• Gastritis
• Humans
• Male
• Middle Aged
• Pyloric Antrum
• Urea
• Urease

PubMed Central ID

• 2883491

Digital Object Identifier (DOI)

• 10.1016/s0140-6736(87)92145-3

start page

• 1174

end page

• 1177

volume

• 1

issue

• 8543

URL

• http://dx.doi.org/10.1016/s0140-6736(87)92145-3