Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats. Academic Article uri icon


  • We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI-induced heart failure. Three months after MI induction, Wistar rats were divided into four groups: Sham; sedentary MI (S-MI); aerobic exercised MI (A-MI); and resistance exercised MI (R-MI). Exercised rats trained three times a week for 12weeks on a treadmill or ladder. Statistical analysis was performed by ANOVA or Kruskal-Wallis test. Functional aerobic capacity was greater in A-MI and strength gain higher in R-MI. Echocardiographic parameters did not differ between infarct groups. Reactive oxygen species production, evaluated by fluorescence, was higher in S-MI than Sham, and lipid hydroperoxide concentration was lower in A-MI than the other groups. Glutathione peroxidase activity was higher in A-MI than S-MI and R-MI. Superoxide dismutase was lower in S-MI than Sham and R-MI. Gastrocnemius cross-sectional area, satellite cell activation and expression of the ubiquitin-proteasome system proteins did not differ between groups. In conclusion, aerobic exercise and resistance exercise improve functional capacity and maximum load carrying, respectively, without changing cardiac remodelling in infarcted rats. In the gastrocnemius, infarction increases oxidative stress and changes antioxidant enzyme activities. Aerobic exercise reduces oxidative stress and attenuates superoxide dismutase and glutathione peroxidase changes.

published proceedings

  • J Cell Mol Med

author list (cited authors)

  • Gomes, M. J., Pagan, L. U., Lima, A., Reyes, D., Martinez, P. F., Damatto, F. C., ... Okoshi, M. P.

citation count

  • 20

complete list of authors

  • Gomes, Mariana J||Pagan, Luana U||Lima, Aline RR||Reyes, David RA||Martinez, Paula F||Damatto, Felipe C||Pontes, Thierres HD||Rodrigues, Eder A||Souza, Lidiane M||Tosta, Ingrid F||Fernandes, Ana AH||Zornoff, Leonardo AM||Okoshi, Katashi||Okoshi, Marina P

publication date

  • May 2020