Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure. Academic Article uri icon


  • Objective. We evaluated the influence of exercise on functional capacity, cardiac remodeling, and skeletal muscle oxidative stress, MAPK, and NF-B pathway in rats with aortic stenosis- (AS-) induced heart failure (HF). Methods and Results. Eighteen weeks after AS induction, rats were assigned into sedentary control (C-Sed), exercised control (C-Ex), sedentary AS (AS-Sed), and exercised AS (AS-Ex) groups. Exercise was performed on treadmill for eight weeks. Statistical analyses were performed with Goodman and ANOVA or Mann-Whitney. HF features frequency and mortality did not differ between AS groups. Exercise improved functional capacity, assessed by maximal exercise test on treadmill, without changing echocardiographic parameters. Soleus cross-sectional areas did not differ between groups. Lipid hydroperoxide concentration was higher in AS-Sed than C-Sed and AS-Ex. Activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase was changed in AS-Sed and restored in AS-Ex. NADPH oxidase activity and gene expression of its subunits did not differ between AS groups. Total ROS generation was lower in AS-Ex than C-Ex. Exercise modulated MAPK in AS-Ex and did not change NF-B pathway proteins. Conclusion. Exercise improves functional capacity in rats with AS-induced HF regardless of echocardiographic parameter changes. In soleus, exercise reduces oxidative stress, preserves antioxidant enzyme activity, and modulates MAPK expression.

published proceedings

  • Oxid Med Cell Longev

author list (cited authors)

  • Gomes, M. J., Martinez, P. F., Campos, D., Pagan, L. U., Bonomo, C., Lima, A., ... Okoshi, M. P.

citation count

  • 38

complete list of authors

  • Gomes, Mariana Janini||Martinez, Paula Felippe||Campos, Dijon Henrique SalomĂ©||Pagan, Luana Urbano||Bonomo, Camila||Lima, Aline Regina Ruiz||Damatto, Ricardo Luiz||Cezar, Marcelo DM||Damatto, Felipe Cezar||Rosa, Camila Moreno||Garcia, Camila Marchiolli||Reyes, David Rafael Abreu||Fernandes, Ana AngĂ©lica Henrique||Fernandes, Denise Castro||Laurindo, Francisco Rafael||Okoshi, Katashi||Okoshi, Marina Politi

publication date

  • January 2016