Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility. Academic Article

abstract

• The colon and small intestine have inherent differences (e.g. redox status) that may explain the variation in cancer occurrence at these two sites. This study examined basal and induced (oxidative challenge) reactive oxygen species (ROS) generation, antioxidant enzyme activity and oxidative DNA damage. Basal ROS and antioxidant enzyme activities in the colon were greater than in the small intestine. During oxidative stress, 8-oxo-deoxyguanosine (8-oxodG) DNA adducts in the colon exceeded levels in the small intestine concomitant with increased ROS. Thus the colon responds to oxidative stress less effectively than the small intestine, possibly contributing to increased cancer incidence at this site.

authors

• Burghardt, Robert
• Carroll, Raymond
• Chapkin, Robert
• Mouneimne, Roula
• Turner, Nancy

published proceedings

• Cancer Lett

author list (cited authors)

• Sanders, L. M., Henderson, C. E., Hong, M. Y., Barhoumi, R., Burghardt, R. C., Carroll, R. J., ... Lupton, J. R.

citation count

• 58

complete list of authors

• Sanders, Lisa M||Henderson, Cara E||Hong, Mee Young||Barhoumi, Rola||Burghardt, Robert C||Carroll, Raymond J||Turner, Nancy D||Chapkin, Robert S||Lupton, Joanne R

publication date

• January 2004

publisher

• Elsevier  Publisher

published in

• Cancer Letters  Journal

keywords

• Animals
• Catalase
• Colon
• Colonic Neoplasms
• DNA Damage
• Disease Susceptibility
• Intestine, Small
• Male
• Nasa Discipline Radiation Health
• Non-NASA Center
• Oxidation-Reduction
• Rats
• Rats, Sprague-Dawley
• Reactive Oxygen Species

PubMed Central ID

• 15142673

Digital Object Identifier (DOI)

• 10.1016/j.canlet.2003.12.007

start page

• 155

end page

• 161

volume

• 208

issue

• 2

URL

• http://dx.doi.org/10.1016/j.canlet.2003.12.007