Enzymatic sculpting of nanoscale and microscale surface topographies. Academic Article uri icon


  • Lithography-free etching of complex surface features is achieved by harnessing the enzyme proteinase K (PK), controlled by bovine serum albumin (BSA), to digest a biodegradable polymer. This bio-sculpting process is used to construct a membraneless filtration device for the size-based isolation and enrichment of cells from whole blood. Copyright 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 29.5

author list (cited authors)

  • Huang, J., Jayaraman, A., & Ugaz, V. M.

citation count

  • 4

complete list of authors

  • Huang, Jen-Huang||Jayaraman, Arul||Ugaz, Victor M

publication date

  • September 2012