Os(II/III) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter. Academic Article

abstract

• DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(II/III) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.

authors

• Sczepanski, Jonathan

published proceedings

• Analyst

altmetric score

• 2

author list (cited authors)

• Aller Pellitero, M., Kundu, N., Sczepanski, J., & Arroyo-Currs, N.

citation count

• 9

complete list of authors

• Aller Pellitero, Miguel||Kundu, Nandini||Sczepanski, Jonathan||Arroyo-Currás, Netzahualcóyotl

publication date

• February 2023

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• The Analyst  Journal

keywords

• Benchmarking
• Biosensing Techniques
• DNA
• Electrochemical Techniques
• Electrodes
• Hydrogen-Ion Concentration
• Methylene Blue

PubMed Central ID

• 36632808

Digital Object Identifier (DOI)

• 10.1039/d2an01901a

start page

• 806

end page

• 813

volume

• 148

issue

• 4

URL

• http://dx.doi.org/10.1039/d2an01901a