Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres. Academic Article uri icon

abstract

  • In recent years, a variety of cycloalkyl groups with quaternary carbons, in particular cyclopropyl and cyclobutyl trifluoromethyl groups, have emerged as promising bioisosteres in drug-like molecules. The modular installation of such bioisosteres remains challenging to synthetic chemists. Alkyl sulfinate reagents have been developed as radical precursors to prepare functionalized heterocycles with the desired alkyl bioisosteres. However, the innate (radical) reactivity of this transformation poses reactivity and regioselectivity challenges for the functionalization of any aromatic or heteroaromatic scaffold. Here we showcase the ability of alkyl sulfinates to engage in sulfurane-mediated C(sp3)-C(sp2) cross-coupling, thereby allowing for programmable and stereospecific installation of these alkyl bioisosteres. The ability of this method to simplify retrosynthetic analysis is exemplified by the improved synthesis of multiple medicinally relevant scaffolds. Experimental studies and theoretical calculations for the mechanism of this sulfur chemistry reveal a ligand-coupling trend under alkyl Grignard activation via the sulfurane intermediate, stabilized by solvation of tetrahydrofuran.

published proceedings

  • Nat Chem

altmetric score

  • 13.2

author list (cited authors)

  • Zhou, M., Tsien, J., Dykstra, R., Hughes, J., Peters, B. K., Merchant, R. R., Gutierrez, O., & Qin, T.

citation count

  • 0

complete list of authors

  • Zhou, Min||Tsien, Jet||Dykstra, Ryan||Hughes, Jonathan ME||Peters, Byron K||Merchant, Rohan R||Gutierrez, Osvaldo||Qin, Tian

publication date

  • April 2023