Discovery of adamantane based highly potent HDAC inhibitors. Academic Article uri icon


  • Herein, we report the development of highly potent HDAC inhibitors for the treatment of cancer. A series of adamantane and nor-adamantane based HDAC inhibitors were designed, synthesized and screened for the inhibitory activity of HDAC. A number of compounds exhibited GI50 of 10-100 nM in human HCT116, NCI-H460 and U251 cancer cells, in vitro. Compound 32 displays efficacy in human tumour animal xenograft model.

published proceedings

  • Bioorg Med Chem Lett

author list (cited authors)

  • Gopalan, B., Ponpandian, T., Kachhadia, V., Bharathimohan, K., Vignesh, R., Sivasudar, V., ... Rajagopal, S.

complete list of authors

  • Gopalan, Balasubramanian||Ponpandian, Thanasekaran||Kachhadia, Virendra||Bharathimohan, Kuppusamy||Vignesh, Radhakrishnan||Sivasudar, Velaiah||Narayanan, Shridhar||Mandar, Bhonde||Praveen, Rajendran||Saranya, Nithyanandan||Rajagopal, Sriram||Rajagopal, Sridharan

publication date

  • May 2013