Devices and Methods for High-Stability Supercooling of Aqueous Media and Biological Matter Patent uri icon


  • Supercooled water or solutions can be destabilized by the nucleation of ice, which can be triggered by a wide range of different mechanisms. Constraining water in a constant-volume (isochoric) container minimizes the effects of many of these mechanisms through thermodynamic, kinetic, and fluid dynamic means, significantly enhancing supercooling stability. This invention describes methods and devices for high-stability and optionally transportable supercooling of aqueous solutions or suspensions, and the stable and long-term preservation of biological matter that may be stored therein.

author list (cited authors)

  • Powell-Palm, M. J., & Rubinsky, B.

complete list of authors

  • Powell-Palm, MJ||Rubinsky, B

publication date

  • October 2022