DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases. Academic Article

abstract

• C1027 is a potent antitumor agent that damages DNA. It has the unusual ability to produce double strand breaks and interstrand cross-links (ICLs) intracellularly, which enable it to initiate concurrent ataxia-telangiestasia mutated (ATM) and Rad-3 related (ATR) independent damage responses. The latter form of damage is not well characterized. We have examined the effect of DNA sequence on C1027 reactivity and found it to be more diverse than previously thought. In addition, analysis of the chemical stability of ICLs suggests that they result from reaction with the deoxyribose ring on one strand but direct addition to a nucleobase on the opposite strand.

authors

• San Pedro, Joanna Maria

published proceedings

• Bioorg Med Chem

author list (cited authors)

• San Pedro, J., Beerman, T. A., & Greenberg, M. M.

citation count

• 11

complete list of authors

• San Pedro, Joanna Maria N||Beerman, Terry A||Greenberg, Marc M

publication date

• August 2012

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry  Journal

keywords

• Aminoglycosides
• DNA
• DNA Damage
• Enediynes
• Hydrogen
• Molecular Structure
• Plasmids

PubMed Central ID

• 22748380

Digital Object Identifier (DOI)

• 10.1016/j.bmc.2012.06.004

start page

• 4744

end page

• 4750

volume

• 20

issue

• 15

URL

• http://dx.doi.org/10.1016/j.bmc.2012.06.004