Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. Academic Article uri icon


  • Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R injury is of clinical interest for improving post-ischemic recovery. A platelet-inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)-modified platelet membrane and cardiac stromal cell-secreted factors to target the heart after I/R injury is introduced. By taking advantage of the natural infarct-homing ability of platelet membrane and the overexpression of PGE2 receptors (EPs) in the pathological cardiac microenvironment after I/R injury, the PINCs can achieve targeted delivery of therapeutic payload to the injured heart. Furthermore, a synergistic treatment efficacy can be achieved by PINC, which combines the paracrine mechanism of cell therapy with the PGE2/EP receptor signaling that is involved in the repair and regeneration of multiple tissues. In a mouse model of myocardial I/R injury, intravenous injection of PINCs results in augmented cardiac function and mitigated heart remodeling, which is accompanied by the increase in cycling cardiomyocytes, activation of endogenous stem/progenitor cells, and promotion of angiogenesis. This approach represents a promising therapeutic delivery platform for treating I/R injury.

published proceedings

  • Adv Funct Mater

author list (cited authors)

  • Su, T., Huang, K. e., Ma, H., Liang, H., Dinh, P., Chen, J., ... Cheng, K. e.

complete list of authors

  • Su, Teng||Huang, Ke||Ma, Hong||Liang, Hongxia||Dinh, Phuong-Uyen||Chen, Justin||Shen, Deliang||Allen, Tyler A||Qiao, Li||Li, Zhenhua||Hu, Shiqi||Cores, Jhon||Frame, Brianna N||Young, Ashlyn T||Yin, Qi||Liu, Jiandong||Qian, Li||Caranasos, Thomas G||Brudno, Yevgeny||Ligler, Frances S||Cheng, Ke