Demonstration of TLR response in O. mykiss by the bacterial 23S rRNA motif Academic Article uri icon


  • Abstract The innate immune system is designed to recognize conserved pathogenic sequences known as pathogen-associated molecular patterns (PAMPs), and it is through the modification of these PAMPs that pathogens can subvert innate immune mechanisms. The target of this study is a conserved motif in the bacterial 23S rRNA, which demonstrates a reduced ability to mutate due to lethality to the organism from degraded ribosomal function. The detection of this motif through the pattern recognition receptor (PRR) TLR13 was demonstrated to elicit an immune response across eight animal phyla and Protistan amoeba phyla through this receptor or its orthologs. In teleost fish, the representative model rainbow trout (Oncorhynchus mykiss) was used to study 23S rRNA recognition by TLR22 and TLR13 initiation of an immune response.

published proceedings

  • The Journal of Immunology

author list (cited authors)

  • Head, K., Kobayashi, K. S., Criscitiello, M. F., & Vijayan, S.

citation count

  • 0

complete list of authors

  • Head, Kelly||Kobayashi, Koichi S||Criscitiello, Michael F||Vijayan, Saptha

publication date

  • May 2019