Photoredox/Nickel-Catalyzed Single-Electron Tsuji-Trost Reaction: Development and Mechanistic Insights. Academic Article uri icon


  • A regioselective, nickel-catalyzed photoredox allylation of secondary, benzyl, and -alkoxy radical precursors is disclosed. Through this manifold, a variety of linear allylic alcohols and allylated monosaccharides are accessible in high yields under mild reaction conditions. Quantum mechanical calculations [DFT and DLPNO-CCSD(T)] support the mechanistic hypothesis of a Ni0 to NiII oxidative addition pathway followed by radical addition and inner-sphere allylation.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 6.05

author list (cited authors)

  • Matsui, J. K., Gutirrez-Bonet, . ., Rotella, M., Alam, R., Gutierrez, O., & Molander, G. A.

citation count

  • 77

complete list of authors

  • Matsui, Jennifer K||Gutiérrez-Bonet, Álvaro||Rotella, Madeline||Alam, Rauful||Gutierrez, Osvaldo||Molander, Gary A

publication date

  • January 2018