Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway. Academic Article uri icon


  • A disulfide made by oxidation of 8-thioguanosine is a supergelator. The hydrogels are redox-responsive, as they disassemble upon either reduction or oxidation of the S-S bond. We also identified this disulfide, and 2 other compounds, as intermediates in oxidative desulfurization of 8-thioG to guanosine.

published proceedings

  • Chem Commun (Camb)

author list (cited authors)

  • Xiao, S., Lee, W., Chen, F. u., Zavalij, P. Y., Gutierrez, O., & Davis, J. T.

complete list of authors

  • Xiao, Songjun||Lee, Wes||Chen, Fu||Zavalij, Peter Y||Gutierrez, Osvaldo||Davis, Jeffery T

publication date

  • January 2020