Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway.

abstract

• A disulfide made by oxidation of 8-thioguanosine is a supergelator. The hydrogels are redox-responsive, as they disassemble upon either reduction or oxidation of the S-S bond. We also identified this disulfide, and 2 other compounds, as intermediates in oxidative desulfurization of 8-thioG to guanosine.

authors

• Gutierrez Santacruz, Osvaldo

published proceedings

• Chem Commun (Camb)

altmetric score

• 1.5

author list (cited authors)

• Xiao, S., Lee, W., Chen, F. u., Zavalij, P. Y., Gutierrez, O., & Davis, J. T.

citation count

• 5

complete list of authors

• Xiao, Songjun||Lee, Wes||Chen, Fu||Zavalij, Peter Y||Gutierrez, Osvaldo||Davis, Jeffery T

publication date

• January 2020

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Chemical Communications  Journal

keywords

• Density Functional Theory
• Disulfides
• Guanosine
• Hydrogels
• Molecular Structure
• Oxidation-Reduction
• Thionucleosides

PubMed Central ID

• 32436517

Digital Object Identifier (DOI)

• 10.1039/d0cc02926b

start page

• 6981

end page

• 6984

volume

• 56

issue

• 51

URL

• http://dx.doi.org/10.1039/d0cc02926b