Multideterminant role of calcium in hippocampal synaptic plasticity. Academic Article

abstract

• Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca(2+)-dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage-dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates.

authors

• Ko, Gladys

published proceedings

• Hippocampus

author list (cited authors)

• Teyler, T. J., Cavus, I., Coussens, C., DiScenna, P., Grover, L., Lee, Y. P., & Little, Z.

citation count

• 90

complete list of authors

• Teyler, TJ||Cavus, I||Coussens, C||DiScenna, P||Grover, L||Lee, YP||Little, Z

publication date

• December 1994

publisher

• Wiley  Publisher

published in

• The Hippocampus  Journal

keywords

• Animals
• Calcium
• Hippocampus
• Humans
• Neuronal Plasticity
• Synapses

PubMed Central ID

• 7704107

Digital Object Identifier (DOI)

• 10.1002/hipo.450040602

start page

• 623

end page

• 634

volume

• 4

issue

• 6

URL

• http://dx.doi.org/10.1002/hipo.450040602