Effects of dexmedetomidine on hemodynamic, oxygenation, microcirculation, and inflammatory markers in a porcine model of sepsis. Academic Article uri icon


  • PURPOSE: To determine whether dexmedetomidine aggravates hemodynamic, metabolic variables, inflammatory markers, and microcirculation in experimental septic shock. METHODS: Twenty-four pigs randomized into: Sham group (n = 8), received saline; Shock group (n = 8), received an intravenous infusion of Escherichia coli O55 (3 109 cells/mL, 0.75 mL/kg, 1 hour); Dex-Shock group (n = 8), received bacteria and intravenous dexmedetomidine (bolus 0.5 mcg/kg followed by 0.7 mcg/kg/h). Fluid therapy and/ornorepinephrine were administered to maintain a mean arterial pressure > 65 mmHg. Hemodynamic, metabolic, oxygenation, inflammatory markers, and microcirculation were assessed at baseline, at the end of bacterial infusion, and after 60, 120, 180, and 240 minutes. RESULTS: Compared to Shock group, Dex-Shock group presented a significantly increased oxygen extraction ratio at T180 (23.1 9.7 vs. 32.5 9.2%, P = 0.0220), decreased central venous pressure at T120 (11.6 1 vs. 9.61 1.2 mmHg, P = 0.0214), mixed-venous oxygen saturation at T180 (72.9 9.6 vs. 63.5 9.2%, P = 0.026), and increased plasma lactate (3.7 0.5 vs. 5.5 1 mmol/L, P = 0.003). Despite the Dex-Shock group having a better sublingual vessel density at T240 (12.5 0.4 vs. 14.4 0.3 mL/m2; P = 0.0003), sublingual blood flow was not different from that in the Shock group (2.4 0.2 vs. 2.4 0.1 mL/kg, P = 0.4418). CONCLUSIONS: Dexmedetomidine did not worsen the hemodynamic, metabolic, inflammatory, or sublingual blood flow disorders resulting from septic shock. Despite inducing a better sublingual vessel density, dexmedetomidine initially and transitorily increased the mismatch between oxygen supply and demand.

published proceedings

  • Acta Cir Bras

altmetric score

  • 1.35

author list (cited authors)

  • Carnicelli, P., Otsuki, D. A., Monteiro Filho, A., Kahvegian, M., Ida, K. K., Auler-Jr, J., Rouby, J., & Fantoni, D. T.

citation count

  • 0

complete list of authors

  • Carnicelli, Paulo||Otsuki, Denise Aya||Monteiro Filho, Adalberto||Kahvegian, Marcia Aparecida Portela||Ida, Keila Kazue||Auler-Jr, José Otavio Costa||Rouby, Jean-Jacques||Fantoni, Denise Tabacchi

publication date

  • January 2022