Synthesis of a ratiometric fluorescent peptide sensor for the highly selective detection of Cd2+. Academic Article uri icon


  • A novel ratiometric fluorescent peptidyl chemosensor (Dansyl-Cys-Pro-Gly-Cys-Trp-NH(2), D-P5) for metal ions detection has been synthesized via Fmoc solid-phase peptide synthesis. The chemosensor exhibited a high selectivity for Cd(2+) over other metal ions including competitive transition and Group I and II metal ions in neutral pH. The fluorescence emission intensity of D-P5 was significantly enhanced in the presence of Cd(2+) by fluorescent resonance energy transfer (FRET) and chelation enhanced fluorescence (CHEF) effects. The binding stoichiometry, detection limit, binding affinity, reversibility and pH sensitivity of the sensor for Cd(2+) were investigated.

published proceedings

  • Bioorg Med Chem Lett

author list (cited authors)

  • Li, Y., Li, L., Pu, X., Ma, G., Wang, E., Kong, J., Liu, Z., & Liu, Y.

citation count

  • 56

complete list of authors

  • Li, Yan||Li, Lianzhi||Pu, Xuewei||Ma, Guolin||Wang, Erqiong||Kong, Jinming||Liu, Zhipeng||Liu, Yangzhong

publication date

  • June 2012