Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR. Academic Article

abstract

• There is strong evidence that physical activity has a profound protective effect against multiple types of cancer. Here, we show that this effect may be mediated by factors released from skeletal muscle during simulated exercise, in situ, which suppress canonical anabolic signaling in breast cancer. We report attenuated growth of MCF7 breast cancer cells in the presence of a rodent-derived exercise conditioned perfusate, independent of prior exercise training. This reduction was concomitant with increased levels of DEPTOR protein and reduced mTOR activity.

authors

• Fluckey, James
• Riechman, Steven

published proceedings

• Front Physiol

altmetric score

• 94.05

author list (cited authors)

• Davis, A. R., Goodenough, C. G., Westerlind, K. C., Strange, R., Deaver, J. W., Ryan, P. J., Riechman, S. E., & Fluckey, J. D.

citation count

• 1

complete list of authors

• Davis, Amanda R||Goodenough, Chelsea G||Westerlind, Kim C||Strange, Robert||Deaver, John W||Ryan, Patrick J||Riechman, Steven E||Fluckey, James D

publication date

• January 2022

publisher

• Frontiers  Publisher

published in

• Frontiers in Physiology  Journal

keywords

• Cell Culture
• Electrical Stimulation
• Myokines
• Protein Synthesis
• Tumor Suppression

PubMed Central ID

• 36388131

Digital Object Identifier (DOI)

• 10.3389/fphys.2022.1033585

start page

• 1033585

volume

• 13

URL

• http://dx.doi.org/10.3389/fphys.2022.1033585