Identifying genes associated with chemotherapy response in ovarian carcinomas based on DNA copy number and expression profiles Conference Paper uri icon

abstract

  • DNA copy number alterations (CNAs) may change transcription profiles and are reported to be associated with chemotherapy response. Using a recently concluded ovarian cancer study derived from the Cancer Genome Atlas (TCGA) Research Network, we selected 98 ovarian cancer samples derived from patients who were only treated with Paclitaxel/Carboplatin after the surgery. A statistical testing procedure was proposed to examine the genes with CNAs and correlated changes in expression level, and their associated response to chemotherapy in progression-free survival. Among 12,042 genes under consideration, 112 genes with CNAs and correlated gene expression levels were found to be associated with progression-free survival (PFS) significantly. The region containing many selected genes, 1p35.1-1p34.2, is closely examined as a candidate segment where CNAs are significantly associated with chemotherapeutic response to Paclitaxel/Carboplatin. Biological processes and molecular functions associated with chemotherapy response were further proposed based on a gene ontology enrichment analysis. ©2011 IEEE.

name of conference

  • 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

published proceedings

  • 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

author list (cited authors)

  • Hsu, F., Serpedin, E., Hsiao, T., Bishop, A., Dougherty, E. R., & Chen, Y

citation count

  • 2

complete list of authors

  • Hsu, Fang-Han||Serpedin, Erchin||Hsiao, Tzu-Hung||Bishop, Alexander JR||Dougherty, Edward R||Chen, Yidong

publication date

  • December 2011

publisher