Identifying genes associated with chemotherapy response in ovarian carcinomas based on DNA copy number and expression profiles
Conference Paper
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Overview
abstract
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DNA copy number alterations (CNAs) may change transcription profiles and are reported to be associated with chemotherapy response. Using a recently concluded ovarian cancer study derived from the Cancer Genome Atlas (TCGA) Research Network, we selected 98 ovarian cancer samples derived from patients who were only treated with Paclitaxel/Carboplatin after the surgery. A statistical testing procedure was proposed to examine the genes with CNAs and correlated changes in expression level, and their associated response to chemotherapy in progression-free survival. Among 12,042 genes under consideration, 112 genes with CNAs and correlated gene expression levels were found to be associated with progression-free survival (PFS) significantly. The region containing many selected genes, 1p35.1-1p34.2, is closely examined as a candidate segment where CNAs are significantly associated with chemotherapeutic response to Paclitaxel/Carboplatin. Biological processes and molecular functions associated with chemotherapy response were further proposed based on a gene ontology enrichment analysis. ©2011 IEEE.
name of conference
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2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)
published proceedings
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2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)
author list (cited authors)
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Hsu, F., Serpedin, E., Hsiao, T., Bishop, A., Dougherty, E. R., & Chen, Y
citation count
complete list of authors
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Hsu, Fang-Han||Serpedin, Erchin||Hsiao, Tzu-Hung||Bishop, Alexander JR||Dougherty, Edward R||Chen, Yidong
publication date
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published in
Research
keywords
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2.1 Biological And Endogenous Factors
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Biotechnology
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Cancer
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Genetic Testing
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Genetics
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Human Genome
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OVARIAN CANCER
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Rare Diseases
Identity
Digital Object Identifier (DOI)
International Standard Book Number (ISBN) 13
Additional Document Info
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URL
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http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=6145287