Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase. Academic Article

abstract

• AIDS caused by the infection of HIV is a prevalent problem today.Rapid development of drug resistance to existing drug classes has called for the discovery of new targets. Within the three major enzymes (i.e., HIV-1 protease, HIV-1 reverse transcriptase and HIV-1 integrase [IN]) of the viral replication cycle, HIV-1 IN has been of particular interest due to the absence of human cellular homolog. HIV-1 IN catalyzes the integration of viral genetic material with the host genome, a key step in the viral replication process. Several novel classes of HIV IN inhibitors have been explored by targeting different sites on the enzyme. This review strives to provide readers with updates on the recent developments of HIV-1 IN inhibitors.

authors

• Lu, Dai

published proceedings

• Future Sci OA

altmetric score

• 4.25

author list (cited authors)

• Choi, E., Mallareddy, J. R., Lu, D., & Kolluru, S.

citation count

• 36

complete list of authors

• Choi, Eungi||Mallareddy, Jayapal Reddy||Lu, Dai||Kolluru, Srikanth

publication date

• January 2018

publisher

• Future Science Group  Publisher

published in

• n2056-5623ISSN  Journal

keywords

• 3′-processing
• Aids/hiv
• Dual Inhibitors
• Hiv Integrase
• Hiv Integrase Inhibitors
• Ledgins
• Strand Transfer Inhibitors

Digital Object Identifier (DOI)

• 10.4155/fsoa-2018-0060

start page

• FSO338

end page

• FSO338

volume

• 4

issue

• 9

URL

• http://dx.doi.org/10.4155/fsoa-2018-0060