Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves Chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity Academic Article uri icon


  • Three extracts of different polarities of Glycyrrhiza glabra L. leaves were characterized and evaluated for their antioxidant, anti-genotoxic and anti-inflammatory activity. In total, thirty components have been identified and quantified through the use of liquid chromatography (LC) with ultraviolet-visible diode-array-detector (UV-vis-DAD) and mass spectrometry (MS). The main components belong to the polyphenols family, being flavonoid and dihydrostilbene derivatives. The extracts have been investigated for their antioxidant, anti-genotoxic and anti-inflammatory activities, which are fundamental requirements of efficacious chemo-preventive agents. The ethyl acetate extract proved to be the most valuable, evidently for the conspicuous presence of several polyphenols, namely flavonoids and dihydrostilbenes.

published proceedings

  • Fitoterapia

altmetric score

  • 3

author list (cited authors)

  • Siracusa, L., Saija, A., Cristani, M., Cimino, F., D'Arrigo, M., Trombetta, D., Rao, F., & Ruberto, G.

citation count

  • 95

complete list of authors

  • Siracusa, Laura||Saija, Antonella||Cristani, Mariateresa||Cimino, Francesco||D'Arrigo, Manuela||Trombetta, Domenico||Rao, Felice||Ruberto, Giuseppe

publication date

  • June 2011