An open science study of ageing in companion dogs Academic Article uri icon

abstract

  • The Dog Aging Project is a long-term longitudinal study of ageing in tens of thousands of companion dogs. The domestic dog is among the most variable mammal species in terms of morphology, behaviour, risk of age-related disease and life expectancy. Given that dogs share the human environment and have a sophisticated healthcare system but are much shorter-lived than people, they offer a unique opportunity to identify the genetic, environmental and lifestyle factors associated with healthy lifespan. To take advantage of this opportunity, the Dog Aging Project will collect extensive survey data, environmental information, electronic veterinary medical records, genome-wide sequence information, clinicopathology and molecular phenotypes derived from blood cells, plasma and faecal samples. Here, we describe the specific goals and design of the Dog Aging Project and discuss the potential for this open-data, community science study to greatly enhance understanding of ageing in a genetically variable, socially relevant species living in a complex environment.

published proceedings

  • Nature

altmetric score

  • 868.12

author list (cited authors)

  • Creevy, K. E., Akey, J. M., Kaeberlein, M., Promislow, D., Barnett, B. G., Benton, B., ... Wilfond, B. S
  • Creevy, K. E., Akey, J. M., Kaeberlein, M., Promislow, D., Barnett, B. G., Benton, B., ... Wilfond, B. S.

citation count

  • 7

complete list of authors

  • Creevy, Kate E||Akey, Joshua M||Kaeberlein, Matt||Promislow, Daniel EL||Barnett, Brian G||Benton, Brooke||Borenstein, Elhanan||Castelhano, Marta G||Chou, Lucy||Collins, Devin||Coleman, Amanda E||Crowder, Kyle||Dunbar, Matthew D||Evans, Jeremy||Fajt, Virginia R||Fitzpatrick, Annette L||Jeffery, Unity||Jonlin, Erica C||Karlsson, Elinor K||Kerr, Kathleen F||Lee, Hannah||Levine, Jonathan M||Ma, Jing||McClelland, Robyn L||McNulty, Kellyn E||Morrill, Kathleen||Nam, Yunbi||Ruple, Audrey||Schwartz, Stephen M||Shrager, Sandi||Snyder-Mackler, Noah||Thistlethwaite, William||Tolbert, M Katherine||Urfer, Silvan R||Wilfond, Benjamin S

publication date

  • February 2022
  • January 1, 2022 11:11 AM

published in