selected publications academic article St. Jean, S. C., Jortner, B. S., Doan, R. N., Dindot, S. V., Johnson, G. S., Bullock, G., ... Porter, B. F. (2022). Pathologic characterization of canine multiple system degeneration in the Ibizan hound. Veterinary Pathology. 59(1), 132-137. Born, H. A., Martinez, L. A., Levine, A. T., Harris, S. E., Mehra, S., Lee, W. L., ... Anderson, A. E. (2021). Early developmental EEG and seizure phenotypes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. ENEURO. 8(2), eneuro.0345-eneu20.2020. Kelly, E., Meng, F., Fujita, H., Morgado, F., Kazemi, Y., Rice, L. C., ... Tsai, P. T. (2020). Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits. Nat Neurosci. 23(9), 1102-1110. Salazar-Medina, A. J., Velazquez-Contreras, E. F., Sugich-Miranda, R., Santacruz, H., Navarro, R. E., Rocha-Alonzo, F., ... Criscitiello, M. F. (2020). Immune response of human cultured cells towards macrocyclic Fe2PO and Fe2PC bioactive cyclophane complexes. PeerJ. 8, e8956-e8956. Dodge, A., Peters, M. M., Greene, H. E., Dietrick, C., Botelho, R., Chung, D., ... Nash, K. R. (2020). Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion. Autism Research. 13(3), 397-409. Berg, E. L., Pride, M. C., Petkova, S. P., Lee, R. D., Copping, N. A., Shen, Y., ... Silverman, J. L. (2020). Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. Translational Psychiatry. 10(1), 39. Dindot, S. V., Doan, R. N., Kuskie, K. R., Hillman, P. R., Whitfield, C. M., McQueen, C. M., ... Cohen, N. D. (2018). Postnatal changes in epigenetic modifications of neutrophils of foals are associated with increased ROS function and regulation of neutrophil function. Dev Comp Immunol. 87, 182-187. Hillman, P. R., Christian, S., Doan, R., Cohen, N. D., Konganti, K., Douglas, K., ... Dindot, S. V. (2017). Genomic imprinting does not reduce the dosage of UBE3A in neurons. Epigenetics & Chromatin. 10(1), 27. Copping, N. A., Christian, S., Ritter, D. J., Islam, M. S., Buscher, N., Zolkowska, D., ... Dindot, S. V. (2017). Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome. Human Molecular Genetics. Alves, B., Cardoso, R. C., Doan, R., Zhang, Y., Dindot, S. V., Williams, G. L., & Amstalden, M. (2017). Nutritional programming of accelerated puberty in heifers: alterations in DNA methylation in the arcuate nucleus. BIOLOGY OF REPRODUCTION. 96(1), 174-184. McQueen, C. M., Whitfield-Cargile, C. M., Konganti, K., Blodgett, G. P., Dindot, S. V., & Cohen, N. D. (2016). TRPM2 SNP genotype previously associated with susceptibility to Rhodococcus equi pneumonia in Quarter Horse foals displays differential gene expression identified using RNA-Seq. BMC GENOMICS. 17(1), 993. Chisholm, N. C., Henderson, M. L., Selvamani, A., Park, M. J., Dindot, S., Miranda, R. C., & Sohrabji, F. (2015). Histone methylation patterns in astrocytes are influenced by age following ischemia. Epigenetics. 10(2), 142-152. McQueen, C. M., Dindot, S. V., Foster, M. J., & Cohen, N. D. (2015). Genetic Susceptibility to Rhodococcus equi. J Vet Intern Med. 29(6), 1648-1659. Ghaffari, N., Sanchez-Flores, A., Doan, R., Garcia-Orozco, K. D., Chen, P. L., Ochoa-Leyva, A., ... Criscitiello, M. F. (2014). Novel transcriptome assembly and improved annotation of the whiteleg shrimp (Litopenaeus vannamei), a dominant crustacean in global seafood mariculture. Scientific Reports. 4(1), 7081. Balaraman, S., Doan, R., Dindot, S., & Miranda, R. (2013). Epigenetic Regulation of MicroRNAs in Fetal Neural Stem Cells: Uncovering Novel Mechanisms of Ethanol Teratology. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY. 97(5), 305-305. Wang, J., Wu, Z., Li, D., Li, N., Dindot, S. V., Satterfield, M. C., Bazer, F. W., & Wu, G. (2012). Nutrition, epigenetics, and metabolic syndrome. Antioxid Redox Signal. 17(2), 282-301. Doan, R., Cohen, N., Harrington, J., Veazey, K., Juras, R., Cothran, G., ... Dindot, S. V. (2012). Identification of copy number variants in horses. Genome Res. 22(5), 899-907. Doan, R., Cohen, N. D., Sawyer, J., Ghaffari, N., Johnson, C. D., & Dindot, S. V. (2012). Whole-genome sequencing and genetic variant analysis of a Quarter Horse mare. BMC GENOMICS. 13(1), 78. Dindot, S., Piccolo, P., Grove, N., Palmer, D., & Brunetti-Pierri, N. (2011). Intrathecal Injection of Helper-Dependent Adenoviral Vectors Results in Long-Term Transgene Expression in Neuroependymal Cells and Neurons. Human Gene Therapy. 22(6), 745-751. Dindot, S. V., Person, R., Strivens, M., Garcia, R., & Beaudet, A. L. (2009). Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions. Genome Res. 19(8), 1374-1383. Dindot, S. V., Antalffy, B. A., Bhattacharjee, M. B., & Beaudet, A. L. (2007). The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Human Molecular Genetics. 17(1), 111-118. Dindot, S. V., Kent, K. C., Evers, B., Loskutoff, N., Womack, J., & Piedrahita, J. A. (2004). Conservation of genomic imprinting at the XIST, IGF2, and GTL2 loci in the bovine. MAMMALIAN GENOME. 15(12), 966-974. Dindot, S. V., Farin, P. W., Farin, C. E., Romano, J., Walker, S., Long, C., & Piedrahita, J. A. (2004). Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses. BIOLOGY OF REPRODUCTION. 71(2), 470-478. Piedrahita, J. A., Mir, B., Dindot, S., & Walker, S. (2004). Somatic Cell Cloning: The Ultimate Form of Nuclear Reprogramming?. Journal of the American Society of Nephrology. 15(5), 1140-1144. Dindot, S. V., Farin, P., Farin, C., Alexander, J., Crosier, E., Walker, S., Long, C., & Piedrahita, J. A. (2004). 35ANALYSIS OF EPIGENETIC MODIFICATIONS AND GENOMIC IMPRINTING IN NUCLEAR TRANSFER DERIVED BOS GAURUS×B. TAURUS CONCEPTI. REPRODUCTION FERTILITY AND DEVELOPMENT. 16(2), 140-140. Archer, G. S., Dindot, S., Friend, T. H., Walker, S., Zaunbrecher, G., Lawhorn, B., & Piedrahita, J. A. (2003). Hierarchical phenotypic and epigenetic variation in cloned swine. BIOLOGY OF REPRODUCTION. 69(2), 430-436. conference paper Piccolo, P., Dindot, S., Grove, N., Palmer, D., & Brunetti-Pierri, N. (2010). Intrathecal injection of HDAd vectors results in long-term transgene expression in neuroepithelial cells and neurons. HUMAN GENE THERAPY. 1395-1395. institutional repository document Dindot, S. V., Christian, S., Murphy, W. J., Berent, A., Panagoulias, J., Schlafer, A., ... Douville, J. (2021). Development of an ASO therapy for Angelman syndrome by targeting an evolutionarily conserved region at the start of the UBE3A-AS transcript Ghaffari, N., Sanchez-Flores, A., Doan, R., Garcia-Orozco, K. D., Chen, P. L., Ochoa-Leyva, A., ... Criscitiello, M. F. (2014). Novel transcriptome assembly and improved annotation of the whiteleg shrimp (Litopenaeus vannamei), a dominant crustacean in global seafood mariculture. Scientific Reports.
co-principal investigator on Integrated Program for Reducing Bovine Respiratory Disease Complex In Beef and Dairy Cattle awarded by United States Department of Agriculture - (Washington D.C., District of Columbia, United States) 2011 - 2017
teaching activities BICH491 Hnr-research Instructor BIMS320 Biomedical Genetics Instructor BIMS421 Advanced Human Genetics Instructor GENE320 Biomedical Genetics Instructor GENE421 Advanced Human Genetics Instructor GENE691 Research Instructor MSCI691 Research Credit: Medical Sci Instructor VTMI689 Sptp: Adv Human Genetics Instructor VTMI691 Research Instructor VTPB485 Directed Studies Instructor
chaired theses and dissertations Doan, Ryan (2013-08). The Identification and Characterization of Copy Number Variants in the Bovine Genome. Hillman, Paul Randolph (2015-05). Analysis of Genomic Imprinting of UBE3A in Neurons. McQueen, Cole M (2015-12). Investigating Genetic Susceptibility to Rhodococcus equi.
education and training Ph.D. in Genetics, Texas A&M University - (College Station, Texas, United States) 2003 B.S. in Molecular and Cell Biology, Texas A&M University - (College Station, Texas, United States) 1999 Baylor College of Medicine - (Houston, Texas, United States) , Postdoctoral Training 2008
awards and honors Outstanding Scientific Achievement Award, conferred by Texas A&M University - (College Station, Texas, United States), 2013
mailing address Texas A&M University Vet Med Pathobiology 4467 TAMU College Station, TX 77843-4467 USA
In the News From parent advocate to nonprofit chief science officer, to biotherapeutic company cofounder - A personal journey through drug development for Angelman Syndrome News Release GeneTx and Ultragenyx Announce Positive Interim Phase 1/2 Data on Investigational GTX-102 Demonstrating Improvement in Patients with Angelman Syndrome News Release GeneTx and Ultragenyx Announce Presentation of Phase 1/2 Data on Investigational GTX-102 in Patients with Angelman Syndrome News Release