Cutaneous Amelanotic Signet-Ring Melanoma in a Siberian Tiger (Panthera tigris altaica). Academic Article

abstract

• A 15-year-old male white Siberian tiger (Panthera tigris altaica) was evaluated for an elevated, ulcerated, cutaneous mass on the right flank. The mass was removed by excisional biopsy and submitted for histopathology. Based on distinct histological features of intracytoplasmic globular material and positive immunohistochemical staining for Melan-A and vimentin, an amelanotic signet-ring melanoma was diagnosed. While in domestic cats this neoplasm is associated with malignancy and a short survival time, the tiger had no local recurrence or related clinical disease approximately 4 years post surgery. Cutaneous melanocytic tumours are rare in big cats, and the findings in this case suggest that amelanotic signet-ring melanoma is not as malignant as its counterpart in domestic cats.

authors

• Wiener, Dominique

published proceedings

• J Comp Pathol

altmetric score

• 0.5

author list (cited authors)

• Hensel, M. E., Wiener, D. J., & Edwards, J. F.

citation count

• 0

complete list of authors

• Hensel, Martha E||Wiener, Dominique J||Edwards, John F

publication date

• November 2021

publisher

• Elsevier  Publisher

published in

• JOURNAL OF COMPARATIVE PATHOLOGY  Journal

keywords

• Amelanotic Melanoma
• Animals
• Cat Diseases
• Cats
• Male
• Melan-a
• Melanoma
• Siberian Tiger
• Signet-ring Cell
• Skin Neoplasms
• Tigers

PubMed Central ID

• 34886982

Digital Object Identifier (DOI)

• 10.1016/j.jcpa.2021.10.009

start page

• 141

end page

• 144

volume

• 189

URL

• http://dx.doi.org/10.1016/j.jcpa.2021.10.009