Functionalized protein-based materials and their uses
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Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx fusions with VEGF and other growth factors, cell signaling proteins, and cell binding proteins can be used to induce angiogenesis. Ubx fibers and mesh, embedded within a tissue engineering scaffold, induce formation of vasculature within the scaffold. The presence of vasculature is necessary to provide oxygen and nutrients to other cells growing within the scaffold.
author list (cited authors)
Bondos, S., Bayless, K., Matthews, K., Patterson, J., Abbey, C., Howell, D., ... Northern, K.
complete list of authors
Bondos, Sarah||Bayless, Kayla||Matthews, Kathleen||Patterson, Jan||Abbey, Colette||Howell, David||Hsiao, Hao-Ching||Churion, Kelly||Tsai, Shang-Pu||Ramasamy, Sandhya||Porterpan, Dustin||Northern, Keira