Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer. Academic Article uri icon


  • Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound 8d inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with improved selectivity towards cancer cells. The antiproliferative activity of 8d is achieved through triggering apoptotic cell death.

published proceedings

  • R Soc Open Sci

author list (cited authors)

  • Fu, B., Li, Y., Peng, S., Wang, X., Hu, J., Lv, L., ... Qin, C.

citation count

  • 1

complete list of authors

  • Fu, Boqiao||Li, Yingjie||Peng, Shaoyong||Wang, Xiaolin||Hu, Jingying||Lv, Long||Xia, Caifen||Lu, Dai||Qin, Caiqin

publication date

  • February 2021