While reactions driven by mechanical force or stress can be labeled mechanochemical, those specifically occurring at a sliding interface inherit the name tribochemical, which stems from the study of friction and wear: tribology. Increased perception of tribochemical reactions has been gained through technological advancement, and the development of new applications remains on-going. This surprising physico-kinetic process offers great potential in novel reaction pathways for synthesis techniques and nanoparticle interactions, and it could prove to be a powerful cross-disciplinary research area among chemists, engineers, and physicists. In this review article, a survey of the history and recent usage of tribochemical reaction pathways is presented, with a focus on forging new compounds and materials with this sustainable synthesis methodology. In addition, an overview of tribochemistry’s current utility as a synthesis pathway is given and compared to that of traditional mechanochemistry.