Posttraining intra-basolateral amygdala scopolamine impairs food- and amphetamine-induced conditioned place preferences.

abstract

• The present study investigated the role of cholinergic muscarinic receptor function within the basolateral amygdala memory in the consolidation of conditioned place preference (CPP) memory. Adult male Long-Evans rats were confined to treatment- or nontreatment-paired compartments for 30 min on 4 alternating days. After training, rats received intrabasolateral amygdala infusions of scopolamine (2.5 microg or 5.0 microg/0.5 microl) or saline. The rats were then given a 20-min test session, and the time spent in each of the compartments was recorded. Immediate posttraining (but not delayed 2 hr) scopolamine (5.0 microg) blocked acquisition of food- and amphetamine-induced CPPs. The findings indicate a time-dependent role for basolateral amygdala muscarinic receptors in memory consolidation underlying CPPs for natural and drug rewards.

authors

• Packard, Mark

published proceedings

• Behav Neurosci

altmetric score

• 1

author list (cited authors)

• Schroeder, J. P., & Packard, M. G.

citation count

• 48

complete list of authors

• Schroeder, Jason P||Packard, Mark G

publication date

• October 2002

publisher

• American Psychological Association (APA)  Publisher

published in

• BEHAVIORAL NEUROSCIENCE  Journal

keywords

• Amphetamine
• Amygdala
• Analysis Of Variance
• Animals
• Brain Mapping
• Central Nervous System Stimulants
• Conditioning, Psychological
• Dose-Response Relationship, Drug
• Drug Interactions
• Food Preferences
• Male
• Memory
• Muscarinic Antagonists
• Rats
• Rats, Long-Evans
• Scopolamine
• Time Factors

Digital Object Identifier (DOI)

• 10.1037//0735-7044.116.5.922

start page

• 922

end page

• 927

volume

• 116

issue

• 5

URL

• http://dx.doi.org/10.1037/0735-7044.116.5.922