Systemic or intra-amygdala injections of glucose facilitate memory consolidation for extinction of drug-induced conditioned reward. Academic Article uri icon


  • The conditioned place preference (CPP) task has been used extensively to investigate the neurobiological bases of drug-induced reward. The initial expression of a CPP involves memory for an association between environmental stimuli and the affective state produced by a rewarding treatment. The present experiments examined the hypothesis that post-trial administration of glucose can facilitate memory consolidation processes underlying the extinction of drug-induced CPP behaviour. Adult male Long-Evans rats acquired an amphetamine CPP, and subsequently received extinction training. Immediately following extinction training, separate groups of rats received peripheral (100 mg/kg, 500 mg/kg, or 2 g/kg) or intra-amygdala (basolateral nucleus; 1.5 micro g/0.5 micro L or 10 micro g/0.5 micro L) injections of glucose or vehicle. Peripheral (100 mg/kg and 2 g/kg) and intra-amygdala (1.5 and 10 micro g) glucose injections facilitated the extinction of amphetamine CPP behaviour relative to vehicle-injected controls. Postextinction trial peripheral or intra amygdala glucose injections that were delayed 2 h had no effect. The findings indicate that: (i) extinction of approach behaviour to drug-associated cues involves the formation of new memories that undergo a time-dependent consolidation process; and (ii), systemic or intra-amygdala administration of a known memory-enhancing agent facilitates extinction of drug-induced CPP behaviour.

published proceedings

  • Eur J Neurosci

author list (cited authors)

  • Schroeder, J. P., & Packard, M. G

citation count

  • 68

complete list of authors

  • Schroeder, Jason P||Packard, Mark G

publication date

  • April 2003