Protein Arginine Methyltransferase 5 in T Lymphocyte Biology. Academic Article

abstract

• Protein arginine methyltransferase 5 (PRMT5) is the major methyltransferase (MT) catalyzing symmetric dimethylation (SDM). PRMT5 regulates developmental, homeostatic and disease processes in vertebrates and invertebrates, and a carcinogenic role has been observed in mammals. Recently, tools generated for PRMT5 loss of function have allowed researchers to demonstrate essential roles for PRMT5 in mouse and human lymphocyte biology. PRMT5 modulates CD4+ and CD8+ T cell development in the thymus, peripheral homeostasis, and differentiation into CD4+ helper T lymphocyte (Th)17 cell phenotypes. Here, we provide a timely review of the milestones leading to our current understanding of PRMT5 in T cell biology, discuss current tools to modify PRMT5 expression/activity, and highlight mechanistic pathways.

authors

• Patrick, Kristin

published proceedings

• Trends Immunol

altmetric score

• 11.55

author list (cited authors)

• Sengupta, S., Kennemer, A., Patrick, K., Tsichlis, P., & Guerau-de-Arellano, M.

citation count

• 13

complete list of authors

• Sengupta, Shouvonik||Kennemer, Austin||Patrick, Kristin||Tsichlis, Philip||Guerau-de-Arellano, Mireia

publication date

• January 2020

publisher

• Elsevier  Publisher

published in

• Trends in Immunology  Journal

keywords

• Animals
• Arginine Methylation
• Autoimmunity
• Cell Differentiation
• Humans
• Lymphocytes
• Prmt5
• Protein-arginine N-methyltransferases
• T-Lymphocytes
• Th17 Cells

Digital Object Identifier (DOI)

• 10.1016/j.it.2020.08.007

start page

• 918

end page

• 931

volume

• 41

issue

• 10

URL

• http://dx.doi.org/10.1016/j.it.2020.08.007