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Patrick, Kristin Assistant Professor


My interests lie in understanding the precise spatial-temporal resolution of RNA processing events in Mtb infected macrophages during early infection, focusing on the following questions: Are gene expression changes upon Mtb infection regulated post-transcriptionally (i.e. at the level of pre-mRNA splicing, mRNA release from chromatin, or mRNA export)? Does Mtb hijack normal post-transcriptional RNA processing events in order to promote its survival in the macrophage? Are Mtb-induced changes dependent on the ESX-1 secretion system and can we implicate any specific bacterial gene products? Working alongside Dr. Robert Watson, my group will work to understand how regulation of RNA metabolism can influence early stages of Mtb pathogenesis, with the eventual goal of modulating said pathways in order to control Mtb infection.

HR job title

  • Assistant Professor