An orthosteric inhibitor of the Ras-Sos interaction. Academic Article uri icon


  • Mimics of -helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Here we describe the design of a cell-permeable synthetic -helix, based on the guanine nucleotide exchange factor Sos, that interferes with Ras-Sos interaction and downregulates Ras signaling in response to receptor tyrosine kinase activation.

published proceedings

  • Nat Chem Biol

altmetric score

  • 13.85

author list (cited authors)

  • Patgiri, A., Yadav, K. K., Arora, P. S., & Bar-Sagi, D.

citation count

  • 251

complete list of authors

  • Patgiri, Anupam||Yadav, Kamlesh K||Arora, Paramjit S||Bar-Sagi, Dafna

publication date

  • January 2011