Impact of the Microbiota on Bacterial Infections during Cancer Treatment. Academic Article uri icon


  • Patients being treated for cancer are at high risk for infectious complications, generally due to colonizing organisms that gain access to sterile sites via disrupted epithelial barriers. There is an emerging understanding that the ability of bacterial pathogens, including multidrug-resistant organisms, to colonize and subsequently infect humans is largely dependent on protective bacterial species present in the microbiome. Thus, herein we review recent studies demonstrating strong correlations between the microbiome of the oncology patient and infections occurring during chemotherapy. An increased knowledge of the interplay between potential pathogens, protective commensals, and the host immune system may facilitate the development of novel biomarkers or therapeutics that could help ameliorate the toll that infections take during the treatment of cancer.

published proceedings

  • Trends Microbiol

author list (cited authors)

  • Galloway-Pea, J., Brumlow, C., & Shelburne, S.

complete list of authors

  • Galloway-Peña, Jessica||Brumlow, Chelcy||Shelburne, Samuel

publication date

  • January 1, 2017 11:11 AM