Comparison of antiinflammatory mechanisms of mango (Mangifera indica L.) and pomegranate (Punica granatum L.) in DSSinduced colitis in rats (372.8) Academic Article uri icon


  • Ulcerative colitis, a chronic inflammation of the large intestine, may increase risk of human colorectal cancer. Several studies have focused on developing natural antiinflammatory products. Polyphenolics from mango (mainly gallotannins) and pomegranate (mainly ellagitannins) have been shown to have potent antiinflammatory properties. To determine the antiinflammatory effects and possible mechanisms of mango and pomegranate juice in DSSinduced colitis, SD rats were administered control, mango, or pomegranate juice, and were exposed to three cycles of 3% DSS followed by 2week recovery period. The levels of protein involved in the mTOR pathway were analyzed by multiplex bead assay, while the transcriptional variation with the mTOR pathway were analyzed by low density PCR arrays. In addition, the levels of several miRNAs involved in the mTOR pathway were measured. Chronic colitis was caused by DSS in rats, and mango and pomegranate juice reduced colon inflammation compared to control juice. Mango juice suppressed the IGF1RAKT/mTOR signaling axis via upregulation of miR126 and downregulation of IR, while pomegranate decreased p70S6K by upregulating miR145 and downregulation of the MEKERK1/2 pathway. These results suggest that polyphenolics of different predominant structure may differentially regulate inflammationinvolved pathways while attenuating DSSinduced colitis.

published proceedings

  • The FASEB Journal

author list (cited authors)

  • Kim, H., Banerjee, N., Ivanov, I., Talcott, S., & MertensTalcott, S.

citation count

  • 2

complete list of authors

  • Kim, Hyemee||Banerjee, Nivedita||Ivanov, Ivan||Talcott, Stephen||Mertensā€Talcott, Susanne

publication date

  • April 2014