Validation of a mathematical model of gene transcription in aggregated cellular systems: application to l1 retrotransposition.
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We present a methodology aimed at partial validation and accuracy-precision assessment of a mathematical model of gene transcription at the cellular level. The method is based on the analysis of time-series measurements aggregated over a large number of cells. Such measurements are typically obtained via reverse transcriptase-polymerase chain reaction (RT-PCR) experiments. The validation procedure presented herein uses as an example data on L1 retrotransposon gene in HeLa cells. The procedure compares model predicted values with the RT-PCR data for L1 by means of the standard Bayesian statistical techniques with the help of modern Markov-Chain Monte-Carlo methodology.
author list (cited authors)
Rempala, G. A., Ramos, K. S., Kalbfleisch, T., & Teneng, I.
complete list of authors
Rempala, Grzegorz A||Ramos, Kenneth S||Kalbfleisch, Ted||Teneng, Ivo