Gonadal hormones and stroke risk: PCOS as a case study. Academic Article

abstract

• It is well known that stroke incidence and outcome is sex-dependent and influenced by age and gonadal hormones. In post-menopausal and/or aged females, declining estrogen levels increases stroke risk. However, women who experience early menopause also have an increase in stroke risk. This suggests that, regardless of age, gonadal hormones regulate stroke risk and severity. This review discusses prolonged gonadal hormone dysfunction in a common female endocrine disorder known as polycystic ovarian syndrome, PCOS, and the associated increased risk of stroke due to resulting hyperandrogenism and metabolic comorbidities.

authors

• Sohrabji, Farida

published proceedings

• Front Neuroendocrinol

altmetric score

• 0.5

author list (cited authors)

• Stewart, C. E., & Sohrabji, F.

citation count

• 9

complete list of authors

• Stewart, Courtney E||Sohrabji, Farida

publication date

• July 2020

publisher

• Elsevier  Publisher

published in

• Frontiers in Neuroendocrinology  Journal

keywords

• Adult
• Aged
• Aged, 80 And Over
• Aging
• Female
• Gonadal Hormones
• Humans
• Hyperandrogenism
• Hyperandrogensism
• Metformin
• Middle Aged
• Polcystic Ovarian Syndrome
• Polycystic Ovary Syndrome
• Risk Factors
• Severity Of Illness Index
• Stroke

PubMed Central ID

• 32640267

Digital Object Identifier (DOI)

• 10.1016/j.yfrne.2020.100853

start page

• 100853

end page

• 100853

volume

• 58

URL

• http://dx.doi.org/10.1016/j.yfrne.2020.100853