Hypoxic tumor microenvironment: Implications for cancer therapy. Academic Article

abstract

• Hypoxia contributes to tumor aggressiveness and promotes growth of many solid tumors that are often resistant to conventional therapies. In order to achieve successful therapeutic strategies targeting different cancer types, it is necessary to understand the molecular mechanisms and signaling pathways that are induced by hypoxia. Aberrant tumor vasculature and alterations in cellular metabolism and drug resistance due to hypoxia further confound this problem. This review focuses on the implications of hypoxia in an inflammatory TME and its impact on the signaling and metabolic pathways regulating growth and progression of cancer, along with changes in lymphangiogenic and angiogenic mechanisms. Finally, the overarching role of hypoxia in mediating therapeutic resistance in cancers is discussed.

authors

• Bayless, Kayla
• Chakrabortty, Abhishek
• Chakraborty, Sanjukta

published proceedings

• Exp Biol Med (Maywood)

altmetric score

• 1

author list (cited authors)

• Roy, S., Kumaravel, S., Sharma, A., Duran, C. L., Bayless, K. J., & Chakraborty, S.

citation count

• 49

complete list of authors

• Roy, Sukanya||Kumaravel, Subhashree||Sharma, Ankith||Duran, Camille L||Bayless, Kayla J||Chakraborty, Sanjukta

publication date

• July 2020

publisher

• SAGE Publications  Publisher

published in

• Experimental Biology and Medicine  Journal

keywords

• Angiogenesis
• Cancer
• Cell Hypoxia
• Cell Respiration
• Chemoresistance
• Hif1⍺
• Humans
• Hypoxia
• Hypoxia-Inducible Factor 1, Alpha Subunit
• Inflammation
• Lymphangiogenesis
• Mitochondria
• Neoplasms
• Radioresistance
• Tumor Microenvironment

PubMed Central ID

• 32594767

Digital Object Identifier (DOI)

• 10.1177/1535370220934038

start page

• 1073

end page

• 1086

volume

• 245

issue

• 13

URL

• http://dx.doi.org/10.1177/1535370220934038