Complement Evasion by Lyme Disease Spirochetes. Academic Article

abstract

• The complement system is an ancient arm of the innate immune system that plays important roles in pathogen recognition and elimination. Upon activation by microbes, complement opsonizes bacterial surfaces, recruits professional phagocytes, and causes bacteriolysis. Borreliella species are spirochetal bacteria that are transmitted to vertebrate hosts via infected Ixodes ticks and are the etiologic agents of Lyme disease. Pathogens that traffic in blood and other body fluids, like Borreliella, have evolved means to evade complement. Lyme disease spirochetes interfere with complement by producing a small arsenal of outer-surface lipoproteins that bind host complement components and manipulate their native activities. Here we review the current landscape of complement evasion by Lyme disease spirochetes and provide an update on recent discoveries.

authors

• Skare, Jon

published proceedings

• Trends Microbiol

altmetric score

• 4.75

author list (cited authors)

• Skare, J. T., & Garcia, B. L.

citation count

• 30

complete list of authors

• Skare, Jon T||Garcia, Brandon L

publication date

• January 2020

publisher

• Elsevier  Publisher

published in

• TRENDS IN MICROBIOLOGY  Journal

keywords

• Animals
• Borrelia Burgdorferi
• Complement Evasion
• Complement System Proteins
• Humans
• Immune Evasion
• Immunity, Innate
• Ixodes
• Lyme Disease
• Pathogenesis

Digital Object Identifier (DOI)

• 10.1016/j.tim.2020.05.004

start page

• 889

end page

• 899

volume

• 28

issue

• 11

URL

• http://dx.doi.org/10.1016/j.tim.2020.05.004

user-defined tag

• 3 Good Health and Well-Being