Micropatterned co-culture model of bacteria and epithelial cells for investigating signal-mediated host-pathogen interactions
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In this paper, we report the development of a micropatterned co-culture technique for co-culture of bacteria and eukaryotic cells for investigating host-pathogen interactions in pathogen infections. A key feature of the proposed model is that pathogens are exposed to an environment similar to the human gastrointestinal tract. This work can be used for developing a fundamental understanding of interkingdom communication and signal recognition during pathogenic infections. 2008 CBMS.