Using soluble polymers in latent biphasic systems. Academic Article uri icon


  • A new strategy for carrying out reactions with a soluble polymer-bound reagent or catalyst is described. In this latent biphasic process, a solvent mixture at the cusp of immiscibility is prepared and used to carry out a reaction under homogeneous conditions. Then, after the reaction is complete, this mixture is perturbed by the addition of solvent or some other perturbing agent to produce a biphasic mixture. The product-containing phase is then separated under liquid/liquid conditions from the polymer-containing phase. The generality of this process is demonstrated using both dye-labeled polymers as surrogates for polymer-bound catalysts and with various polymer-bound organic and transition metal catalysts or reagents. In cases where a polymeric catalyst is used, the addition of fresh solvent and substrate reforms the original mixture allowing facile reuse of the catalyst.

published proceedings

  • J Am Chem Soc

altmetric score

  • 3

author list (cited authors)

  • Bergbreiter, D. E., Osburn, P. L., Smith, T., Li, C., & Frels, J. D.

citation count

  • 61

complete list of authors

  • Bergbreiter, David E||Osburn, Philip L||Smith, Thomas||Li, Chunmei||Frels, Jonathon D

publication date

  • May 2003