STEREOSPECIFIC ENZYMATIC-HYDROLYSIS OF PHOSPHORUS-SULFUR BONDS IN CHIRAL ORGANOPHOSPHATE TRIESTERS Academic Article uri icon

abstract

  • The bacterial phosphotriesterase has been shown to be capable of catalyzing the hydrolysis of a P-S bond in organophosphate triesters. The Vmax values for the hydrolysis of the insecticides, acephate (O, S-dimethyl N-acetlphosphoramidothioate) and methamidophos (O, S-dimethyl phosphoramidothioate) are 140 and 6 min-1, respectively. The (SP)-enantiomers are hydrolyzed at a rate that is 100-fold faster than the (RP)-enantiomers. 1994.

published proceedings

  • BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

author list (cited authors)

  • CHAE, M. Y., POSTULA, J. F., & RAUSHEL, F. M.

citation count

  • 39

complete list of authors

  • CHAE, MY||POSTULA, JF||RAUSHEL, FM

publication date

  • June 1994