STEREOSPECIFIC ENZYMATIC-HYDROLYSIS OF PHOSPHORUS-SULFUR BONDS IN CHIRAL ORGANOPHOSPHATE TRIESTERS Academic Article

abstract

• The bacterial phosphotriesterase has been shown to be capable of catalyzing the hydrolysis of a P-S bond in organophosphate triesters. The Vmax values for the hydrolysis of the insecticides, acephate (O, S-dimethyl N-acetlphosphoramidothioate) and methamidophos (O, S-dimethyl phosphoramidothioate) are 140 and 6 min-1, respectively. The (SP)-enantiomers are hydrolyzed at a rate that is 100-fold faster than the (RP)-enantiomers. 1994.

authors

• Raushel, Frank

published proceedings

• BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

author list (cited authors)

• CHAE, M. Y., POSTULA, J. F., & RAUSHEL, F. M.

citation count

• 39

complete list of authors

• CHAE, MY||POSTULA, JF||RAUSHEL, FM

publication date

• June 1994

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

keywords

• 34 Chemical Sciences
• 3402 Inorganic Chemistry

Digital Object Identifier (DOI)

• 10.1016/S0960-894X(01)80516-3

start page

• 1473

end page

• 1478

volume

• 4

issue

• 12