Stereospcific enzymatic hydrolysis of phosphorus-sulfur bonds in chiral organophosphate triesters Academic Article uri icon

abstract

  • The bacterial phosphotriesterase has been shown to be capable of catalyzing the hydrolysis of a P-S bond in organophosphate triesters. The Vmax values for the hydrolysis of the insecticides, acephate (O, S-dimethyl N-acetlphosphoramidothioate) and methamidophos (O, S-dimethyl phosphoramidothioate) are 140 and 6 min-1, respectively. The (SP)-enantiomers are hydrolyzed at a rate that is 100-fold faster than the (RP)-enantiomers. © 1994.

author list (cited authors)

  • Chae, M. Y., Postula, J. F., & Raushel, F. M.

citation count

  • 34

publication date

  • June 1994