A small library of peptidomimetics to systematically vary and test the effects of X(1) constraints Academic Article uri icon


  • A library of 47 peptidomimetics of YGGFLRFa was prepared wherein 32 of these contained 2,3-methanoleucine. This library was tested for binding the neuropeptide FF receptor where neuropeptide FF is FLFQPQRFa, an anti-opiate peptide. This study illustrates how conformational constraints can be systematically varied in a library format to determine the best conformational restrictions for the desired activity.

published proceedings


author list (cited authors)

  • Burgess, K., Godbout, C., Li, W., & Payza, K.

citation count

  • 1

complete list of authors

  • Burgess, K||Godbout, C||Li, W||Payza, K

publication date

  • November 1996