A small library of peptidomimetics to systematically vary and test the effects of X(1) constraints Academic Article

abstract

• A library of 47 peptidomimetics of YGGFLRFa was prepared wherein 32 of these contained 2,3-methanoleucine. This library was tested for binding the neuropeptide FF receptor where neuropeptide FF is FLFQPQRFa, an anti-opiate peptide. This study illustrates how conformational constraints can be systematically varied in a library format to determine the best conformational restrictions for the desired activity.

authors

• Burgess, Kevin

published proceedings

• BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

author list (cited authors)

• Burgess, K., Godbout, C., Li, W., & Payza, K.

citation count

• 1

complete list of authors

• Burgess, K||Godbout, C||Li, W||Payza, K

publication date

• November 1996

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

keywords

• 2,3-methanoleucine
• Anti-opiate
• Fmrfa

Digital Object Identifier (DOI)

• 10.1016/S0960-894X(96)00516-1

start page

• 2761

end page

• 2764

volume

• 6

issue

• 22

URL

• http://dx.doi.org/10.1016/s0960-894x(96)00516-1