HR job title
- Associate Professor
- Contact Info
- 9794369916
Thangavel, Samikkannu Associate Professor
Positions
- Associate Professor, Pharmacy Practice, Irma Lerma Rangel School of Pharmacy
Our lab is predominantly interested in the neuropathogenesis of HIV and drug abuse. We are elucidating the role of HIV and drugs of abuse in energy dysregulation, which ultimately may lead the neurodegeneration. We examine the metabolic signatures through inflammasome profiles, mitochondrial biogenesis, and epigenetics. We use in vitro, ex vivo and a transgenic rat model system in our experiments. Our goal is to develop novel diagnostics tests and treatments for neuroAIDs and neurologic damage related to drugs of abuse.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Ramasamy, T., Doke, M., McLaughlin, J. P., & Samikkannu, T.
(2023).
Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA. Brain, Behavior, and Immunity - Health.
31, 100659-100659.
-
Doke, M., McLaughlin, J. P., Baniasadi, H., & Samikkannu, T.
(2022).
Sleep Disorder and Cocaine Abuse Impact Purine and Pyrimidine Nucleotide Metabolic Signatures. 12(9), 869-869.
-
Doke, M., McLaughlin, J. P., Cai, J. J., Pendyala, G., Kashanchi, F., Khan, M. A., & Samikkannu, T.
(2022).
HIV-1 Tat and cocaine impact astrocytic energy reservoirs and epigenetic regulation by influencing the LINC01133-hsa-miR-4726-5p-NDUFA9 axis. Molecular Therapy : Nucleic Acids.
29, 243-258.
-
Doke, M., Kashanchi, F., Khan, M. A., & Samikkannu, T.
(2022).
HIV-1 Tat and cocaine coexposure impacts piRNAs to affect astrocyte energy metabolism. Epigenomics.
14(5), 261-278.
-
Sundar, V., McLaughlin, J. P., & Samikkannu, T.
(2022).
Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection. Molecular Brain.
15(1), 69.
-
Sundar, V., Ramasamy, T., Doke, M., & Samikkannu, T.
(2022).
Psychostimulants influence oxidative stress and redox signatures: the role of DNA methylation. Redox Report.
27(1), 53-59.
-
Doke, M., Kashanchi, F., Khan, M. A., & Samikkannu, T.
(2021).
HIV-1 Tat and cocaine impact astrocytic energy reservoir influence on miRNA epigenetic regulation. Genomics.
113(6), 3461-3475.
-
Sivalingam, K., Doke, M., Khan, M. A., & Samikkannu, T.
(2021).
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells. Scientific Reports.
11(1), 21335.
-
Doke, M., Jeganathan, V., McLaughlin, J. P., & Samikkannu, T.
(2021).
HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation. Epigenetics.
16(9), 980-999.
-
Sivalingam, K., Cirino, T. J., McLaughlin, J. P., & Samikkannu, T.
(2021).
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration. Molecular Neurobiology.
58(2), 490-504.
-
Doke, M., Ramasamy, T., Sundar, V., McLaughlin, J. P., & Samikkannu, T.
(2021).
Proteomics Profiling with SWATH-MS Quantitative Analysis of Changes in the Human Brain with HIV Infection Reveals a Differential Impact on the Frontal and Temporal Lobes. Brain Sciences.
11(11), 1438-1438.
-
Doke, M., Pendyala, G., & Samikkannu, T.
(2021).
Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes. PLoS ONE.
16(6), e0252895-e0252895.
-
Sivalingam, K., & Samikkannu, T.
(2020).
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes. Brain Sciences.
10(9), 611-611.
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Pimentel, E., Sivalingam, K., Doke, M., & Samikkannu, T.
(2020).
Effects of Drugs of Abuse on the Blood-Brain Barrier: A Brief Overview. Frontiers in Neuroscience.
14, 513.
-
Thangavel, S., Mulet, C. T., Atluri, V., Agudelo, M., Rosenberg, R., Devieux, J. G., & Nair, M.
(2018).
Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters. Antioxidants and Redox Signaling.
28(4), 324-337.
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Atluri, V., Pilakka-Kanthikeel, S., Garcia, G., Jayant, R. D., Sagar, V., Samikkannu, T., Yndart, A., & Nair, M.
(2016).
Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages. Scientific Reports.
6(1), 27864.
-
Samikkannu, T., Atluri, V., & Nair, M.
(2016).
HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling. Scientific Reports.
6(1), 31784.
-
Atluri, V., Jayant, R. D., Pilakka-Kanthikeel, S., Garcia, G., Samikkannu, T., Yndart, A., Kaushik, A., & Nair, M.
(2016).
Development of TIMP1 magnetic nanoformulation for regulation of synaptic plasticity in HIV-1 infection. 11, 4287-4298.
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Agudelo, M., Figueroa, G., Parira, T., Yndart, A., Muoz, K., Atluri, V., Samikkannu, T., & Nair, M. P.
(2016).
Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. PLoS ONE.
11(6), e0156421-e0156421.
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Kurapati, K., Samikkannu, T., Atluri, V., & Nair, M.
(2015).
Cell cycle checkpoints and pathogenesis of HIV-1 infection: a brief overview. Journal of Basic and Clinical Physiology and Pharmacology.
26(1), 1-11.
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Samikkannu, T., Rao, K., Salam, A., Atluri, V., Kaftanovskaya, E. M., Agudelo, M., ... Nair, M.
(2015).
HIV Subtypes B and C gp120 and Methamphetamine Interaction: Dopaminergic System Implicates Differential Neuronal Toxicity. Scientific Reports.
5(1), 11130.
-
Kurapati, K., Atluri, V. S., Samikkannu, T., Garcia, G., & Nair, M.
(2015).
Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview. Frontiers in Microbiology.
6, 1444.
-
Agudelo, M., Figueroa, G., Yndart, A., Casteleiro, G., Muoz, K., Samikkannu, T., Atluri, V., & Nair, M. P.
(2015).
Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Frontiers in Microbiology.
6, 1452.
-
Atluri, V., Hidalgo, M., Samikkannu, T., Kurapati, K., Jayant, R. D., Sagar, V., & Nair, M.
(2015).
Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update. Frontiers in Cellular Neuroscience.
9, 212.
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Samikkannu, T., Ranjith, D., Rao, K., Atluri, V., Pimentel, E., El-Hage, N., & Nair, M.
(2015).
HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. Frontiers in Microbiology.
6, 614.
-
Atluri, V., Hidalgo, M., Samikkannu, T., Kurapati, K., & Nair, M.
(2015).
Synaptic Plasticity and Neurological Disorders in Neurotropic Viral Infections. Neural Plasticity.
2015, 138979-14.
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Thangavel, S., Rao, A., Kesava Rao, V. K., & Madhavan, P.
(2014).
Commentary of Drugs of Abuse and HIV Infection in South Florida, USA. 1(1),
-
Samikkannu, T., Atluri, V., Arias, A. Y., Rao, K., Mulet, C. T., Jayant, R. D., & Nair, M.
(2014).
HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders. Current HIV Research.
12(6), 397-405.
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Ding, H., Sagar, V., Agudelo, M., Pilakka-Kanthikeel, S., Atluri, V., Raymond, A., Samikkannu, T., & Nair, M. P.
(2014).
Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation. Nanotechnology.
25(5), 055101-055101.
-
Samikkannu, T., Rao, K., Kanthikeel, S. P., Atluri, V., Agudelo, M., Roy, U., & Nair, M.
(2014).
Immunoneuropathogenesis of HIV-1 clades B and C: role of redox expression and thiol modification. Free Radical Biology and Medicine.
69, 136-144.
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Atluri, V., Pilakka-Kanthikeel, S., Samikkannu, T., Sagar, V., Kurapati, K., Saxena, S. K., ... Nair, M.
(2014).
Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder. Molecular Brain.
7(1), 37.
-
Kurapati, K., Samikkannu, T., Atluri, V., Kaftanovskaya, E., Yndart, A., & Nair, M.
(2014).
-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A. PLoS ONE.
9(11), e112818-e112818.
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Samikkannu, T., Rao, K., Ding, H., Agudelo, M., Raymond, A. D., Yoo, C., & Nair, M.
(2014).
Immunopathogenesis of HIV infection in cocaine users: role of arachidonic acid. PLoS ONE.
9(8), e106348-e106348.
-
Agudelo, M., Yndart, A., Morrison, M., Figueroa, G., Muoz, K., Samikkannu, T., & Nair, M. P.
(2013).
Differential expression and functional role of cannabinoid genes in alcohol users. Drug and Alcohol Dependence.
133(2), 789-793.
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Samikkannu, T., Rao, K., Arias, A. Y., Kalaichezian, A., Sagar, V., Yoo, C., & Nair, M.
(2013).
HIV infection and drugs of abuse: role of acute phase proteins. Journal of Neuroinflammation.
10(1), 113.
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Kurapati, K., Atluri, V., Samikkannu, T., & Nair, M.
(2013).
Ashwagandha (Withania somnifera) reverses -amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND). PLoS ONE.
8(10), e77624-e77624.
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Rao, K., Samikkannu, T., Dakshayani, K. B., Zhang, X., Sathaye, S. S., Indap, M. A., & Nair, M.
(2012).
Chemopreventive potential of an ethyl acetate fraction from Curcuma longa is associated with upregulation of p57(kip2) and Rad9 in the PC-3M prostate cancer cell line. Asian Pacific Journal of Cancer Prevention (APJCP).
13(3), 1031-1038.
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Nair, M., & Samikkannu, T.
(2012).
Differential regulation of neurotoxin in HIV clades: role of cocaine and methamphetamine. Current HIV Research.
10(5), 429-434.
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Reddy, P., Gandhi, N., Samikkannu, T., Saiyed, Z., Agudelo, M., Yndart, A., Khatavkar, P., & Nair, M.
(2012).
HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry.
61(5), 807-814.
-
Kurapati, K., Samikkannu, T., Kadiyala, D. B., Zainulabedin, S. M., Gandhi, N., Sathaye, S. S., ... Nair, M.
(2012).
Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line. Journal of Basic and Clinical Physiology and Pharmacology.
23(4), 139-146.
-
Agudelo, M., Gandhi, N., Saiyed, Z., Pichili, V., Thangavel, S., Khatavkar, P., Yndart-Arias, A., & Nair, M.
(2011).
Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). Alcoholism: Clinical and Experimental Research.
35(8), 1550-1556.
-
Saiyed, Z. M., Gandhi, N., Agudelo, M., Napuri, J., Samikkannu, T., Reddy, P., ... Nair, M.
(2011).
HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry.
58(6), 656-664.
-
Samikkannu, T., Agudelo, M., Gandhi, N., Reddy, P., Saiyed, Z. M., Nwankwo, D., & Nair, M.
(2011).
Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS. Journal of NeuroVirology.
17(3), 230-238.
-
Kurapati, V.
(2011).
Proteomics Profiling and Cytotoxic Effect of Curcuma longa on Prostate Cancer. The Open Proteomics Journal.
4(1), 1-11.
-
Samikkannu, T., Rao, K., Gandhi, N., Saxena, S. K., & Nair, M.
(2010).
Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS. Journal of NeuroVirology.
16(4), 255-263.
-
Gandhi, N., Saiyed, Z. M., Napuri, J., Samikkannu, T., Reddy, P., Agudelo, M., ... Nair, M.
(2010).
Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder. Journal of NeuroVirology.
16(4), 294-305.
-
Gandhi, N., Saiyed, Z., Thangavel, S., Rodriguez, J., Rao, K., & Nair, M.
(2009).
Differential effects of HIV type 1 clade B and clade C Tat protein on expression of proinflammatory and antiinflammatory cytokines by primary monocytes. AIDS RESEARCH AND HUMAN RETROVIRUSES.
25(7), 691-699.
-
Samikkannu, T., Saiyed, Z. M., Rao, K., Babu, D. K., Rodriguez, J. W., Papuashvili, M. N., & Nair, M.
(2009).
Differential regulation of indoleamine-2,3-dioxygenase (IDO) by HIV type 1 clade B and C Tat protein. AIDS RESEARCH AND HUMAN RETROVIRUSES.
25(3), 329-335.
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Samikkannu, T., Thomas, J. J., Bhat, G. J., Wittman, V., & Thekkumkara, T. J.
(2006).
Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury. American Journal of Physiology: Renal Physiology.
291(1), F162-F175.
-
Thangavel, S., Dash, K., & Chaurasia, S. C.
(2001).
A simple vapour phase decomposition (VPD) of quartz powder in a polypropylene vessel and determination of phosphorus by spectrophotometry. Talanta.
55(3), 501-507.
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Samikkannu, T., & Devaraj, S. N.
(1997).
Effect of methacrylonitrile on rat lung antioxidant enzymes. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY.
59(6), 894-900.
-
Samikkannu, T., & Devaraj, S. N.
(1997).
Effect of methacrylonitrile on rat lung mitochondria and microsomes. MEDICAL SCIENCE RESEARCH.
25(2), 129-132.
-
Samikkannu, T., Vasanthakumari, V., & Devaraj, S. N.
(1997).
Haematological and erythrocyte membrane changes induced by methacrylonitrile. Toxicology Letters.
92(1), 15-20.
-
Samikkannu, T., & Devaraj, S. N.
(1997).
Toxic effect of methacrylonitrile on rat lung. Journal of Clinical Biochemistry and Nutrition.
23(1), 27-31.
-
Tamizhselvi, R., Samikkannu, T., & Niranjali, S.
(1995).
Pulmonary phospholipid changes induced by butylated hydroxy toluene, an antioxidant, in rats. Indian Journal of Experimental Biology.
33(10), 796-797.
-
Ramasamy, T., Doke, M., McLaughlin, J. P., & Samikkannu, T.
(2023).
Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA. Brain, Behavior, and Immunity - Health.
31, 100659-100659.
-
chapter
-
Agudelo, M., Saiyed, Z., Samikkannu, T., Khatavkar, P., Gandhi, N., Nair, N., & Nair, M.
(2010).
Role of Dendritic Cells in HIV Infection: DC-SIGN and Novel Therapeutic Approaches. DENDRITIC CELLS: TYPES, LIFE CYCLES AND BIOLOGICAL FUNCTIONS.
(pp. 167-177).
-
Agudelo, M., Saiyed, Z., Samikkannu, T., Khatavkar, P., Gandhi, N., Nair, N., & Nair, M.
(2010).
Role of Dendritic Cells in HIV Infection: DC-SIGN and Novel Therapeutic Approaches. DENDRITIC CELLS: TYPES, LIFE CYCLES AND BIOLOGICAL FUNCTIONS.
(pp. 167-177).
-
conference paper
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Thangavel, S., Jeganathan, V., McLaughlin, J. P., & Ramasamy, R.
(2019).
HIV- Tat and Cocaine Impact Astrocytic DNA Methylation. Journal of Neuroimmune Pharmacology.
363-363.
-
Huang, W., Han, H., Du, W., Thangavel, S., & Chang, S. L.
(2018).
BINGE DRINKING CONTRIBUTING TO OPIOID USE DISORDERS. Alcoholism: Clinical and Experimental Research.
36A-36A.
-
Huang, W., Thangavel, S., Han, H., & Chang, S.
(2018).
Modulation of glial cells of adolescent mice given binge treatment with ethanol. Journal of Neuroimmune Pharmacology.
S37-S37.
-
Huang, W., Han, H., Du, W., Thangavel, S., & Chang, S.
(2018).
Sensitization to morphine's anti-nociception in C57BL/6J mice having binge exposure to ethanol. Journal of NeuroVirology.
S36-S37.
-
Huang, W., Han, H., Du, W., Thangavel, S., & Chang, S.
(2018).
Sensitization to morphine's anti-nociception in C57BL/6J mice having binge exposure to ethanol. Journal of Neuroimmune Pharmacology.
S36-S37.
-
Huang, W., Thangavel, S., Han, H., & Chang, S.
(2018).
Modulation of glial cells of adolescent mice given binge treatment with ethanol. Journal of NeuroVirology.
S37-S37.
-
Thangavel, S., Atluri, V., & Nair, M. P.
(2017).
Cocaine and HIV Upregulate Glycolytic Enzymes and Mitochondrial Biogenesis in Astrocytes. Journal of Neuroimmune Pharmacology.
S73-S74.
-
Atluri, V., Pilakka-Kanthikeel, S., Garcia, G., Jayant, R. D., Sagar, V., Thangavel, S., Yndart, A., & Nair, M.
(2017).
Inflammasome Gene Expression and their role in HIV and Cocaine Induced Apoptosis. Journal of Neuroimmune Pharmacology.
S49-S50.
-
Thangavel, S., Rao, K., Agudelo, M., Atluri, V., Mulet, C., & Nair, M. P.
(2015).
HIV and Morphine: Oxidative Stress Impact Cell Cycle Regulation and Neurodegeneration. Journal of Neuroimmune Pharmacology.
S104-S104.
-
Atluri, V., Hernandez, O., Hidalgo, M., Kurapati, K., Thangavel, S., Pilakka-Kanthikeel, S., ... Nair, M.
(2015).
Methamphetamine treatment and HIV-1 infection dysregulate Synaptic plasticity in SKNMC neuronal cells. Journal of Neuroimmune Pharmacology.
S59-S60.
-
Kurapati, V., Samikkannu, T., Atluri, V., Yndart, A., & Nair, M.
(2015).
beta-Amyloid, HIV-1 Infection and Drugs of Abuse Induced Neurodegeneration and Protective Effects of Ashwagandha. Journal of Neuroimmune Pharmacology.
S82-S82.
-
Kurapati, K., Thangavel, S., Atluri, V., Yndart, A. A., & Nair, M.
(2014).
Ashwagandha (Withania somnifera) reverses HIV-1 induced neurodegeneration via attenuation of beta-Amyloid plaques: Implications in HIV-Associated Neurocognitive Disorders (HAND). Journal of Neuroimmune Pharmacology.
29-30.
-
Agudelo, M., Yndart, A., Figueroa, G., Munoz, K., Atluri, V., Thangavel, S., & Nair, M. P.
(2014).
Cannabinoid Agonists Regulate Alcohol-induced Inflammation in Human Dendritic Cells. Journal of Neuroimmune Pharmacology.
3-4.
-
Ding, H., Yatfung, C., Raymond, A., Atluri, V., Roy, U., Yndart-Arias, A., ... Nair, M.
(2014).
Development of hybrid nanocarrier (Au/Fe3O4) for active drug delivery to brain to eliminate HIV-1 persistence. Journal of Neuroimmune Pharmacology.
14-14.
-
Thangavel, S., Rao, K., Ding, H., Agudelo, M., Atluri, V., Raymond, A., ... Nair, M. P.
(2014).
Immunopathogenesis of HIV-1 Infection in Cocaine users: Role of Arachidonic Acid. Journal of Neuroimmune Pharmacology.
55-55.
-
Roy, U., Ding, H., Kanthikeel, S. P., Raymond, A., Atluri, V., Yndart-Arias, A., ... Nair, M.
(2014).
MAGNETIC NANOPARTICLE FOR TARGETTED ANTI-HIV DRUG DELIVERY IN IN VIVO MODEL. Journal of Neuroimmune Pharmacology.
48-49.
-
Raymond, A. D., Hong, D., Roy, U., Yndarta-Arias, A., Agudelo, M., Munoz, K., ... Nair, M. P.
(2014).
Polydrug mediated effects on HIV Nef plus exosome release and neuropathogenesis is modulated by Nef peptide magnetic nanocarriers. Journal of Neuroimmune Pharmacology.
46-47.
-
Atluri, V., Kanthikeel, P. S., Rao, K., Sagar, V., Thangavel, S., Ding, H., ... Nair, M.
(2014).
Role of HDAC2 and miR-485 in regulation of synaptic plasticity genes in HIV infection: Implication in HAND. Journal of Neuroimmune Pharmacology.
6-6.
-
Kurapati, V., Atluri, V., Samikkannu, T., Yndart, A. A., & Nair, M.
(2013).
ASHWAGANDHA (WITHANIA SOMNIFERA) REVERSES B-AMYLOID INDUCED NEURONAL TOXICITY: IMPLICATIONS IN HAND. Journal of Neuroimmune Pharmacology.
422-422.
-
Ding, H., Agudelo, M., Kanthikeel, S. P., Guduru, R., Sagar, V., Atluri, V., Thangavel, S., & Nair, M. N.
(2013).
DUAL MECHANISM ENHANCED BBB CROSSING BY TRANSFERRIN CONJUGATED FLUORESCENT MAGNETIC LIPOSOME. Journal of Neuroimmune Pharmacology.
414-414.
-
Atluri, V., Sudheesh, P. K., Samikkannu, T., Vijaya, P., Ding, H., Raymond, A. D., & Nair, M.
(2013).
EFFECT OF NICOTINE ON SYNAPTIC PLASTICITY GENE EXPRESSION IN HIV-1 INFECTION: IMPLICATION IN HAND. Journal of Neuroimmune Pharmacology.
438-438.
-
Raymond, A. D., Yndart-Arias, A., Agudelo, M., Munoz, K., Alturi, V. S., Pilakka, S., Thangavel, S., & Nair, M. P.
(2013).
HIV NEUROPATHOGENESIS: ROLE OF NEF plus EXOSOMES (EXNEF), METHAMPHETAMINE AND OPIATES. Journal of Neuroimmune Pharmacology.
430-431.
-
Thangavel, S., Rao, K., Raymond, A., Ding, H., Atluri, V., & Nair, M. P.
(2013).
IMMUNOPATHOGENIC MECHANISMS OF HIV-1 CLADE B AND C: ROLE OF DOPAMINERGIC SYSTEM. Journal of Neuroimmune Pharmacology.
434-434.
-
Thangavel, S., Santiago, E. M., & Nair, M.
(2012).
Neuropathogenic Mechanisms by HIV-1 Clade B And C: Role of Lipid Rafts. Journal of Neuroimmune Pharmacology.
S78-S79.
-
Pichili, V. B., Saiyed, Z., Samikkannu, T., Agudelo, M., Gandhi, N., Yndart, A., & Nair, M. P.
(2011).
Activation of the Antioxidant Defensive Enzymes Against HIV-1 gp120 are Mediated by Oxidative Stress and Elevated Intracellular Calcium Levels. Journal of Neuroimmune Pharmacology.
S55-S56.
-
Khatavkar, P., Bryant, V., Rosenberg, R., Malow, R., Devieux, J., Saiyed, Z., ... Nair, M.
(2011).
Association of Dopamine Receptor D2 C957T Gene SNP in Learning and Memory Among HIV-Positive Alcohol Abusers. Journal of Neuroimmune Pharmacology.
S51-S51.
-
Agudelo, M., Spadola, C., Yndart, A., Gandhi, N., Saiyed, Z., Pichili, V. B., Samikkannu, T., & Nair, M. P.
(2011).
Differential Expression of Cannabinoid Genes in Alcoholics. Journal of Neuroimmune Pharmacology.
S23-S23.
-
Saiyed, Z. M., Gandhi, N. H., Napuri, J., Yndart, A., Agudelo, M., Pichili, V. B., Samikkannu, T., & Nair, M. N.
(2011).
Differential Regulation of Neuroplasticity Associated Genes by HIV-1B and C Clades. Journal of Neuroimmune Pharmacology.
S57-S57.
-
Samikkannu, T., Saiyed, Z., Agudelo, M., Reddy, P. V., Nwankwo, D., Gandhi, N., ... Nair, M. P.
(2011).
Differential Regulation of Thiol Modification by HIV-1 Clade B and C Protein. Journal of Neuroimmune Pharmacology.
S57-S58.
-
Agudelo, M., Spadola, C., Yndart, A., Gandhi, N., Saiyed, Z., Reddy, P., Samikkannu, T., & Nair, M.
(2011).
EXPRESSION OF HISTONE DEACETYLASE 2 (HDAC2) IN HUMAN MONOCYTE-DERIVED DENDRITIC CELLS (MDDCS) TREATED WITH ALCOHOL. Alcoholism: Clinical and Experimental Research.
239A-239A.
-
Gandhi, N., Agudelo, M., Saiyed, Z. M., Adriana, Y., Spadola, C., Pichili, V. B., ... Nair, M. N.
(2011).
Molecular Mechanism of Immunosuppression by Cocaine in HIV-1 Infected Subjects: Role of TLR3. Journal of Neuroimmune Pharmacology.
S31-S31.
-
Agudelo, M., Saiyed, Z., Gandhi, N., Samikkannu, T., Khatavkar, P., & Nair, M.
(2010).
Effects of Alcohol on Cannabinoid (CB2) and Serotonin (5-HT3) Receptors in the Human Neuroblastoma Cell Line, SK-N-MC, and the Role of Histone Deacetylase 2 (HDAC2). Journal of Neuroimmune Pharmacology.
S39-S39.
-
Saiyed, Z. M., Gandhi, N., Agudelo, M., Samikkannu, T., Pichili, V., Napuri, J., Khatavkar, P., & Nair, M.
(2010).
HIV-1 Tat upregulates expression of histone deacetylase-2 in human neurons: Implication for HAND. Journal of NeuroVirology.
75-76.
-
Gandhi, N., Agudelo, M., Saiyed, Z., Samikkannu, T., Napuri, J., Khatavkar, P., & Nair, M.
(2010).
Histone Deacetylase Activity in Development of HIV-Associated Neurocognitive Disorder. Journal of Neuroimmune Pharmacology.
S46-S46.
-
Samikkannu, T., Agudelo, M., Gandhi, N., Reddy, P., & Nair, M.
(2010).
Human Immunodeficiency Virus type-1 Glade B and C gp120 Inhibit NMDA-receptor mediated induction of Arachidonic Acid: Implications on Neuro-AIDS. Journal of NeuroVirology.
76-76.
-
Samikkannu, T., Agudelo, M., Gandhi, N., & Nair, M. P.
(2010).
Neuropathogenic Mechanisms of HIV-1 Clade B and C: Role of Methamphetamine (METH). Journal of Neuroimmune Pharmacology.
S53-S53.
-
Rodriguez, J. W., Rodriguez, M., Rodriguez, M., Lopez-Cepero, C., Samikkannu, T., Boukli, N. M., ... Rios-Olivares, E.
(2009).
Comparative Immunovirological Study between Buprenorphine and Methadone Using Human Lymphocytes and Glial Cells. Journal of NeuroVirology.
80-81.
-
Gandhi, N. H., Saiyed, Z. M., Thangavel, S., Rodriguez, J., Rao, K., & Nair, M.
(2009).
Differential Effects of HIV-1 Clade B and Clade C Tat Protein on Expression of Pro- and Anti-inflammatory Cytokines by Primary Monocytes. Journal of NeuroVirology.
30-30.
-
Thangavel, S., Kurapati, K. V., Babu, D., Saiyed, Z., Gandhi, N., Boukli, N., Rodriguez, J. W., & Nair, M.
(2009).
HIV-1 Clade B and C Tat differentially Induces Indoleamine-2, 3-Dioxygenase (IDO) and Serotonin in Immature Dendritic Cells (IDC): Implications for Neuro-AIDS. Journal of NeuroVirology.
98-98.
-
Boukli, N. M., Samikkannu, T., Ricaurte, M., Rodriguez, J. W., Cubano, L., & Nair, M.
(2009).
Proteomic Fingerprints of Primary Human Neurons treated with HIV-1 Clade B and C Proteins: Implications for Neuro-AIDS. Journal of NeuroVirology.
11-11.
-
Thekkumkara, T., Smith, J., Thomas, J., Thangavel, S., & Gunaje, J.
(2006).
Hyperglycemia alters angiotensin type 1 receptor expression through MAP-kinase signaling pathway in liver cells. The FASEB Journal.
A969-A969.
-
Thekkumkara, T. J., Thomas, B. E., Gunaje, J. B., & Thangavel, S.
(2005).
Glucose mediated downregulation of human angiotensin typel receptor gene expression in proximal tubule epithelial cells is induced by PKC epsilon. The FASEB Journal.
A873-A873.
-
Samikkannu, T., Thomas, J. J., Gunaje, J. B., & Thekkumkara, T. J.
(2004).
Glucose induced activation of mitogen activated protein kinases and downstream molecular events in human proximal tubular epithelial cells. Molecular Biology of the Cell.
246A-246A.
-
Gunaje, J. B., Samikkannu, T., Thomas, J. J., & Thekkumkara, T. J.
(2004).
Alpha thrombin rapidly induces tyrosine phosphorylation of glucose regulated protein-75 related stress protein(s) in lung fibroblast cells. Molecular Biology of the Cell.
127A-128A.
-
Thangavel, S., Jeganathan, V., McLaughlin, J. P., & Ramasamy, R.
(2019).
HIV- Tat and Cocaine Impact Astrocytic DNA Methylation. Journal of Neuroimmune Pharmacology.
363-363.
-
institutional repository document
-
Sivalingam, K., Cirino, T. J., McLaughlin, J. P., & THANGAVEL, S.
(2020).
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF-Transcriptional Mediated Neurodegeneration
-
Sivalingam, K., Cirino, T. J., McLaughlin, J. P., & THANGAVEL, S.
(2020).
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF-Transcriptional Mediated Neurodegeneration
Research
principal investigator on
Teaching
teaching activities
- BIOT685 Directed Studies Instructor
- PHAR713 Ipt Iv: Neurology Pain Mgmt Instructor
- PHAR726 Microbiology/immunology Instructor
- PHAR789 Sptp:pharmacogenomics Instructor
- PHAR813 Ipt Viii: Onc, Trnsplt, Genomc Instructor
- PHSC685 Directed Studies Instructor
- PHSC691 Research Instructor
Background
education and training
- Ph.D. in Biochemistry and Molecular Biology, University of Madras - (Chennai, Tamil Nadu, India) 2000
Contact
first name
- Samikkannu
has last name
- Thangavel
mailing address
-
1010 W. Avenue B
MSC 131
College Station, TEXAS 77845
USA
-
159 Reynolds Medical Building
College Station, TEXAS 77845
USA
Other
In the News
- thangavel@tamu.edu